Time to initial antibiotic administration, and short-term mortality among patients admitted with community-acquired severe infections with and without the presence of systemic inflammatory response syndrome: a follow-up study

Emergency Medicine Journal : EMJ
Daniel Pilsgaard HenriksenAnnmarie Touborg Lassen

Abstract

The prognosis for patients with severe infection is related to early treatment, including early administration of antibiotics. The study aim was to compare the short-term mortality among patients admitted with severe infection with and without systemic inflammatory response syndrome (SIRS) at arrival, and to ascertain whether the presence of SIRS might affect the timing of antibiotic administration. In this retrospective follow-up study, we included all adult patients (≥15 years) presenting to a medical emergency department in the period between September 2010 and August 2011 with a first-time admission of community-acquired severe infection (infection with evidence of organ dysfunction), with and without SIRS at arrival. The presence of SIRS was defined as two or more of the criteria according to the American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) definitions. Cases were identified by manual chart review using predefined criteria of infection. Data on vital signs, laboratory values and antibiotic treatment were obtained electronically. We included 1169 patients with infection and organ dysfunction, treated with antibiotics within 24 h after arrival (median age 76.1 years (IQR 63.1-83.5), 567 ...Continue Reading

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Citations

Aug 23, 2016·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Julian M WilliamsJeffrey Lipman
Apr 14, 2020·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Mathieu OberlinXavier Bobbia
May 14, 2017·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Peter Bank PedersenAnnmarie Touborg Lassen

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