PMID: 8971286Dec 1, 1996Paper

Time to maximum effect of lansoprazole on gastric pH in normal male volunteers

Alimentary Pharmacology & Therapeutics
N J Bell, R H Hunt

Abstract

The time to maximum inhibition of gastric acidity resulting from repeated oral dosing with lansoprazole 30 mg daily for 7 days was studied in nine healthy male volunteers. Twenty-four hour intragastric pH monitoring was performed before treatment and on days 1, 3, 5 and 7 of dosing with lansoprazole. Blood samples were taken for the estimation of plasma lansoprazole concentrations. Lansoprazole 30 mg increased mean 24-h intragastric pH to 3.57 on day 1 compared with baseline mean pH of 2.11 (P < 0.05). The mean intragastric pH during the morning period (08.00-13.00 h) was significantly higher on days 3, 5 and 7 than on day 1, but no consistent differences between day 1, 3, 5 and 7 were noted for subsequent periods (13.00-18.00, 18.00-21.00 and 23.00-07.00 h). There were no differences in mean pH between days 3, 5 and 7. Intragastric pH was maintained above pH 3 for 54.7, 60.1, 61.9 and 67.4% of the time on days 1, 3, 5 and 7, respectively. Lansoprazole pharmacokinetic parameters did not change with daily dosing. The area under the lansoprazole plasma concentration-time curve correlated with the intragastric pH (P < 0.005). Lansoprazole 30 mg raised intragastric pH significantly from baseline on day 1 to a maximum effect as earl...Continue Reading

Citations

Jan 3, 2001·Alimentary Pharmacology & Therapeutics·N BellR H Hunt
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·J D GardnerM Robinson
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·J-Q HuangR H Hunt
Jul 29, 2005·Journal of Gastroenterology and Hepatology·Chander M PathakKrishan L Khanduja
Oct 1, 2010·Journal of Gastroenterology and Hepatology·Hyung-Keun KimIn-Sik Chung
Mar 28, 2001·Journal of Clinical Pharmacology·T A PuchalskiW J Jusko
Feb 28, 2014·World Journal of Gastroenterology : WJG·Seung Bae YoonMyung-Gyu Choi
Sep 11, 2012·Clinics and Research in Hepatology and Gastroenterology·Sachio HataOsamu Yokosuka
Feb 14, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chien-Chu LinTzong-Hsi Lee
May 15, 2004·Alimentary Pharmacology & Therapeutics·J W FrestonC Q Lee
Dec 19, 2003·Journal of Clinical Pharmacology·Kyung-Sang YuByoung-Seok Moon
Jan 28, 2010·The American Journal of Medicine·Dean T EurichSumit R Majumdar
Sep 16, 2016·British Journal of Clinical Pharmacology·Kiana KeyvanjahAlvin Wong
Mar 8, 2018·Digestion·Mariko UmezawaKatsuhiko Iwakiri
Feb 9, 2019·Journal of Gastroenterology and Hepatology·Tai-Cherng LiouShou-Chuan Shih
Jan 3, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Yoshimasa HoshikawaKatsuhiko Iwakiri
Jun 18, 2020·Journal of Clinical Medicine·Yu-Chio WangTai-Cherng Liou
Aug 28, 1998·Gastroenterology·M RektorschekK Melchers

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