Time to methotrexate treatment in patients with rheumatoid arthritis referred to hospital

Scandinavian Journal of Rheumatology
A de ThurahK Stengaard-Pedersen

Abstract

To describe time to methotrexate (MTX) treatment among patients with a first-time diagnosis of rheumatoid arthritis (RA) in a hospital-based department of rheumatology. Using prescription data, we conducted a large cohort study in the County of Aarhus, Denmark, including all patients with a first-time diagnosis of RA. We used Kaplan-Meier estimates to compute the cumulative probability of MTX treatment start with follow-up starting on the date of referral. We defined early treatment start as MTX initiation within 90 days after referral. Among 1516 RA patients, a total of 703 (46%) started MTX treatment during the study period. The overall median time to treatment start was 120 days [interquartile range (IQR) 19-557]. Patients included in 2000-2006 had an earlier MTX treatment start compared with patients included in 1996-1999 [adjusted incidence rate ratio (IRR) 1.83, 95% confidence interval (CI) 1.55-2.16]. Patients with a C-reactive protein (CRP) level>300 nmol/L had an earlier MTX treatment start compared with patients with a moderate CRP level (adjusted IRR 1.36, 95% CI 1.16-1.73). Only 21% of the patients started MTX within 90 days after referral and those were mainly patients included in later years and patients with a hi...Continue Reading

References

May 3, 2003·Journal of Clinical Epidemiology·Vincent de GrootLex M Bouter
May 29, 2003·British Journal of Cancer·H T SørensenJ A Baron
Sep 14, 2004·Annals of the Rheumatic Diseases·D AletahaJ S Smolen
Dec 14, 2004·Arthritis and Rheumatism·Jasvinder A SinghSiamak Noorbaloochi
Dec 22, 2004·British Journal of Cancer·H T SørensenJ A Baron
Feb 1, 2005·European Journal of Epidemiology·Merete PedersenMorten Frisch
Aug 1, 2007·Arthritis and Rheumatism·Gabriela SchmajukDaniel H Solomon
Oct 15, 2008·Rheumatology International·Jens K PedersenKim Hørslev-Petersen
Nov 6, 2008·Rheumatology·P KielyUNKNOWN Early Rheumatoid Arthritis Network

❮ Previous
Next ❯

Citations

Jul 21, 2010·Current Rheumatology Reports·Elena MyasoedovaSherine E Gabriel
Jul 6, 2019·British Journal of Clinical Pharmacology·Catherine J LucasJennifer H Martin
Dec 18, 2013·The Journal of Rheumatology·Noriyuki YamakawaTsuneyo Mimori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cardiopulmonary Rehabilitation and Prevention
Timothy R McConnellTroy A Klinger
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Mark T OstermanJames D Lewis
© 2021 Meta ULC. All rights reserved