Time-to-reach Target Calprotectin Level in Newly Diagnosed Patients With Inflammatory Bowel Disease

Journal of Pediatric Gastroenterology and Nutrition
Sjoukje-Marije HaismaPatrick F van Rheenen

Abstract

Treatment targets in inflammatory bowel disease (IBD) move away from controlling symptoms towards complete recovery of the intestinal mucosa. Currently, the most frequently used noninvasive surrogate marker of mucosal healing is a faecal calprotectin concentration in the target range. This study tested if there was a relation between time-to-reach target calprotectin and first flare. We prospectively included new-onset IBD patients ages 17 and younger in a cloud-based registry (FastForwardCare) and followed them for at least 52 weeks. They were treated according to Dutch national guidelines that advocate a step-up approach. Time-to-reach target was defined as the first calprotectin measurement below 250 μg/g after the start of induction therapy. Time-to-first flare was the time from the first calprotectin measurement below 250 μg/g until reappearance of symptoms with calprotectin values above 250 μg/g. We included 76 patients (luminal Crohn disease [CD] 43); ulcerative colitis [UC] 33). Median age at diagnosis was, respectively 14.5 and 14.1 years. Median time-to-reach target calprotectin was 37 weeks in CD and 11 weeks in UC patients (Log-rank test, P = 0.001). Once the calprotectin target was reached, time-to-first flare was ...Continue Reading

References

May 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·J S HyamsJ T Boyle
Mar 15, 2006·Gastroenterology·Laurent BeaugerieJacques Cosnes
Aug 12, 2008·Gastroenterology·Gwenola Vernier-MassouilleJean Frédéric Colombel
Oct 17, 2009·Inflammatory Bowel Diseases·Bénédicte PigneurJacques Cosnes
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Sep 3, 2010·Inflammatory Bowel Diseases·Michael D KappelmanPeter Margolis
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Aug 6, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletWendy Kampman
May 31, 2014·Inflammatory Bowel Diseases·Aranzazu Jauregui-AmezagaMaría Pellise
Jun 10, 2014·Journal of Crohn's & Colitis·F M RuemmeleUNKNOWN European Society of Pediatric Gastroenterology, Hepatology and Nutrition
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Aug 24, 2018·Journal of Crohn's & Colitis·Christian MaaserUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR

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Citations

Jul 17, 2020·Scandinavian Journal of Gastroenterology·Kaija-Leena Kolho, Henrik Alfthan
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele
Apr 3, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Olga Maria NardoneFabiana Castiglione

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Methods Mentioned

BETA
ELISA
biopsies

Software Mentioned

FastForwardCare
OpenEpi
SPSS
GraphPad Prism
GraphPad

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