Time to Separate Persistent From Recurrent Differentiated Thyroid Cancer: Different Conditions With Different Outcomes

The Journal of Clinical Endocrinology and Metabolism
Giulia SapuppoGabriella Pellegriti

Abstract

Differentiated thyroid cancer (DTC) has an excellent prognosis, but up to 20% of patients with DTC have disease events after initial treatment, indistinctly defined as persistent/recurrent disease. To evaluate the prevalence and outcome of "recurrent" disease (relapse after being 12 months disease-free) compared with "persistent" disease (present ab initio since diagnosis). Retrospective analysis of persistent/recurrent disease in patients with DTC (1990 to 2016) with 6.5 years of mean follow-up. Tertiary referral center for thyroid cancer. In total, 4292 patients all underwent surgery ± 131I treatment of DTC. DTC cure of disease persistence or recurrence. A total of 639 of 4292 (14.9%) patients had disease events after initial treatment, most (498/639, 78%) with persistent disease and 141 (22%) with recurrent disease. Relative to patients with recurrent disease, patients with persistent disease were significantly older (mean age 46.9 vs 45.7 years) and with a lower female to male ratio (1.9/1 vs 4.8/1). Moreover, in this group, structured disease was more frequent (65.7% vs 41.1%), and more important, distant metastases were significantly more frequent (38.4% vs 17.0%). At multivariate analysis, male sex (OR = 1.7), age (OR = ...Continue Reading

References

Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·E L Mazzaferri, R T Kloos
Jun 11, 2005·Endocrine-related Cancer·M Xing
Nov 14, 2006·Human Pathology·Jean Jacques MichelsStephane Bardet
Sep 24, 2009·Thyroid : Official Journal of the American Thyroid Association·Jen-Der LinTzu-Chieh Chao
Feb 16, 2010·Thyroid : Official Journal of the American Thyroid Association·Luc G T MorrisIan Ganly
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 11, 2011·The Journal of Clinical Endocrinology and Metabolism·M BrassardUNKNOWN THYRDIAG Working Group
Jan 18, 2012·Clinical Endocrinology·Fernanda VaismanR Michael Tuttle
Feb 22, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, H Gilbert Welch
Oct 25, 2016·The Lancet. Diabetes & Endocrinology·Jena D FrenchMabel Ryder
Apr 1, 2017·JAMA : the Journal of the American Medical Association·Hyeyeun LimCari M Kitahara
Jun 25, 2017·Journal of Endocrinological Investigation·G SapuppoG Pellegriti
Mar 20, 2018·Journal of Endocrinological Investigation·G SapuppoG Pellegriti
Apr 15, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·R Michael Tuttle

❮ Previous
Next ❯

Citations

Sep 17, 2019·Thyroid : Official Journal of the American Thyroid Association·Afshan ZahediStan Van Uum
Oct 24, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiang LiWeibo Xia
Jan 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Lina LiuBin Liu
Mar 19, 2020·Thyroid : Official Journal of the American Thyroid Association·Maria PapaleontiouMegan R Haymart
May 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Lynn A Burmeister, Tyler Drake
Oct 13, 2019·World Journal of Surgery·Claudio SpinelliGabriele Materazzi
Apr 25, 2020·AJNR. American Journal of Neuroradiology·J M DebnamD Schellingerhout
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Luigi De NapoliGabriele Materazzi
Apr 24, 2021·World Journal of Surgery·Claudio SpinelliSilvia Strambi
Jun 30, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ying KouAnren Kuang
Jun 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Tian TianBin Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jasna MihailovicDolores Srbovan
Thyroid : Official Journal of the American Thyroid Association
Rafael Selbach ScheffelAna Luiza Maia
© 2022 Meta ULC. All rights reserved