Time-trends in the prescribing of gastroprotective agents to primary care patients initiating low-dose aspirin or non-steroidal anti-inflammatory drugs: a population-based cohort study

British Journal of Clinical Pharmacology
Margaretha F Warlé-van HerwaardenPeter A G M De Smet

Abstract

Low-dose aspirin (LDA) and non-steroidal-anti-inflammatory drugs (NSAIDs) both increase the risk of upper gastrointestinal events (UGIEs). In the Netherlands, recommendations regarding the prescription of gastroprotective agents (GPAs) in LDA users were first issued in 2009 in the HARM-Wrestling consensus. National guidelines on gastroprotective strategies (GPSs) in NSAID users were issued in the first part of the preceding. The aim of the present study was to examine time-trends in GPSs in patients initiating LDA and those initiating NSAIDs between 2000 and 2012. Within a large electronic primary healthcare database, two cohorts were selected: (i) patients newly prescribed LDA and (ii) patients newly prescribed NSAIDs between 2000 and 2012. Patients who had been prescribed a GPA in the previous six months were excluded. For both cohorts, patients' risk of a UGIE was classified as low, moderate or high, based on the HARM-Wrestling consensus, and the presence of an adequate GPSwas determined. A total of 37 578 patients were included in the LDA cohort and 352 025 patients in the NSAID cohort. In both cohorts, an increase in GPSs was observed over time, but prescription of GPAs was lower in the LDA cohort. By 2012, an adequate GPS...Continue Reading

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Citations

Nov 22, 2017·The International Journal of Pharmacy Practice·Makiko IwasawaMitsutaka Takada
Apr 6, 2016·European Journal of Gastroenterology & Hepatology·Patricia M L A van den BemtMichael H J Verhofstad
Aug 29, 2018·International Journal of Environmental Research and Public Health·María Jesús LallanaMaría José Rabanaque
Jun 28, 2016·International Journal of Clinical Pharmacy·Kevin HamiltonShawn Bugden
Dec 8, 2020·Scandinavian Journal of Gastroenterology·Peter Fentz HaastrupDorte Ejg Jarbøl

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