Time trends of childhood cancer mortality rates: a report from the Childhood Cancer Registry of Piedmont, Italy, 1971-1998

Pediatric Blood & Cancer
Luisa ZuccoloCorrado Magnani

Abstract

Time changes in mortality rates can be used to suggest future trends in the prognosis of childhood cancer. Estimates provided from recent studies led to divergent previsions of future trends. In this study we used data from the population-based Childhood Cancer Registry of Piedmont (CCRP) in order to measure the decrease in mortality. The study included 1,060 deaths in the period 1971-1998. Analyses were carried out using Poisson regression models and considered separately the total tumours, acute lymphoblastic leukaemia (ALL) and tumours of the central nervous system (CNS). We observed a progressive decline in the mortality rates: for all tumours the estimated annual percentage change was -3.6% (P < 0.05), for ALL it was -5.2%, (P < 0.05) and for CNS tumours it was -3.8% (P < 0.05). The statistical test for effect modification due to age at death was not significant. For all cancer types, the Poisson model fits the data well, corresponding to an exponential decrease of mortality rates and leading to the conclusion that current therapies, despite their proven effectiveness, are not sufficient to cure all cases of childhood cancer.

References

Apr 20, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F LeviF Lucchini
Jul 17, 2001·Medical and Pediatric Oncology·L Parker, A W Craft
Oct 5, 2002·Cancer·Gemma GattaFranco Berrino
Feb 13, 2003·Pediatric Clinics of North America·Gregory H Reaman
Apr 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G PastoreC Magnani

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Citations

Jan 1, 1995·Revue D'épidémiologie Et De Santé Publique·C La VecchiaA Decarli
Aug 23, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L YangN Sakamoto
Mar 22, 2006·Pediatric Blood & Cancer·Karina de Cássia Braga Ribeiro, Célia Beatriz Gianotti Antoneli
Apr 25, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Luisa ZuccoloCorrado Magnani
Apr 14, 2009·Journal of Pediatric Surgery·Haitao ZhuYong Yu

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