Time window in cholinomimetic ability to rescue long-term potentiation in neurodegenerating anti-nerve growth factor mice.

Journal of Alzheimer's Disease : JAD
Nicola OrigliaAntonino Cattaneo

Abstract

A deficit in cortical cholinergic synaptic transmission is a common feature of cognitive and behavioral impairment observed in neurodegenerative pathologies. AD11 transgenic mice producing blocking antibodies against Nerve Growth Factor (NGF) are characterized by a progressive neurodegenerative phenotype defined by the deposition of amyloid peptide, intracellular neurofibrillary tangles and by a marked cholinergic depletion. We exploited AD11 mice to develop a functional assay to investigate the impact of cholinergic deficit on cortical synaptic plasticity impairment at different neurodegenerative stages. In particular, we investigated the time course of long-term potentiation (LTP) impairment in neocortex of AD11 mice and potential rescue by acute pharmacological treatment with Acetylcholine (ACh) or the cholinergic agonist Galantamine (GAL). We showed that LTP starts being absent in AD11 mice at 2 months, an age corresponding to early neurodegenerative stage characterized by the first observed decrease in number of basal forebrain cholinergic neurons (BFCNs) without overt cortical neurodegeneration. We demonstrated that acute ACh or GAL treatment fully reverts LTP impairment in 2 month old AD11 mice. In contrast, cholinergic ...Continue Reading

Citations

Feb 8, 2008·Genes, Brain, and Behavior·K SchindowskiL Buée
Sep 4, 2012·Molecular Neurobiology·Antonino Cattaneo, Pietro Calissano
Feb 27, 2010·Developmental Neurobiology·P CalissanoG Amadoro
Mar 23, 2017·Biochemistry. Biokhimii︠a︡·N K IsaevE E Genrikhs
Aug 2, 2012·Neural Plasticity·José Fernando Maya-Vetencourt, Nicola Origlia

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