Time-window of early detection of response to concurrent chemoradiation in cervical cancer by using diffusion-weighted MR imaging: a pilot study

Radiation Oncology
Ying LiuZhaoxiang Ye

Abstract

To investigate the feasibility of DWI in evaluating early therapeutic response of uterine cervical cancer to concurrent chemoradiation (CCR) and establish optimal time window for early detection of treatment response. This was a prospective study and informed consent was obtained from all patients. Thirty-three patients with uterine cervical cancer who received CCR underwent conventional MRI and DWI examinations prior to therapy (base-line) and at 3 days (postT1), 7 days (postT2), 14 days (postT3), 1 month (postT4) and 2 months (postT5) after the therapy initiated. Tumor response was determined by comparing the base-line and postT5 MRI by using RECIST criterion. Percentage ADC change (γADC) of complete response (CR) group at each follow up time was greater than that of partial response (PR) group, and the differences were significant at postT3 (p = 0.007), postT4 (p = 0.001), and postT5 (p = 0.019). There was positive correlation between γADC at each follow-up time and percentage size reduction at postT5. The day of 14 after the therapy initiated can be considered as the optimal time for monitoring early treatment response of uterine cervical cancer to CCR, and the representative and sensitive index was γADC. With the cut-off v...Continue Reading

References

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Citations

Jun 20, 2020·AJR. American Journal of Roentgenology·Bahar MansooriDaniella F Pinho
Aug 23, 2017·Insights Into Imaging·Evelyn DappaAndreas M Hötker
Oct 31, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Li YuanYi-Kai Xu
Feb 16, 2021·Frontiers in Oncology·Petra J van HoudtUulke A van der Heide
Apr 20, 2019·The Indian Journal of Radiology & Imaging·Sunita DashottarNishant Lohia

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Methods Mentioned

BETA
imaging technique
imaging techniques

Software Mentioned

AW4
Statistical Package for the Social Sciences ( SPSS

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