Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia

European Journal of Pharmacology
J Ren, S P Finklestein

Abstract

Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral artery in rats. In the current study, we examined the time dependence of bFGF infusion on infarct reduction, and the effect of co-infusion of bFGF with heparin. We found a significant reduction in infarct volume when the bFGF infusion (50 microg/kg per h for 3 h) was begun up to 3 h, but not 4 h after the onset of ischemia. The infarct reducing effects of bFGF were not altered by co-infusion of heparin. These results are potentially important in light of the ongoing clinical trials of intravenous bFGF in acute stroke.

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Citations

Jun 30, 2000·Biochemical and Biophysical Research Communications·Y KataokaY Watanabe
Dec 24, 2004·Acta Neuropathologica·Yun-Hong DingYuchuan Ding
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·David A Greenberg, Kunlin Jin
Jun 28, 2002·Brain Research. Brain Research Reviews·Ronen R Leker, Esther Shohami
Feb 21, 2013·ACS Chemical Neuroscience·Norihito MurayamaTeruyoshi Inoue
Feb 9, 2002·Journal of Anatomy·Diane R GoddardArthur M Butt
Sep 3, 2011·Expert Opinion on Biological Therapy·Maurizio Paciaroni, Julien Bogousslavsky
Aug 27, 2003·Journal of Pharmacological Sciences·Kohji Fukunaga, Takayuki Kawano
Mar 27, 2003·Neurosurgery·Tetsuji SekiyaShigeharu Suzuki
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Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Kuniyasu WadaSeth P Finklestein
May 29, 2002·Pediatric Research·Katherine H PeterssonBarbara S Stonestreet
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Bi-Wei SongWilliam M Pardridge

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