Timed hypocaloric food restriction alters the synthesis and expression of vasopressin and vasoactive intestinal peptide in the suprachiasmatic nucleus

Brain Research
José P AndradeNikolai V Lukoyanov

Abstract

In mammals, the main circadian pacemaker is located in the suprachiasmatic nucleus (SCN) and its most potent synchronizer is the daily variation of the intensity of light. However, other nonphotic cues, such as timed food restriction, can induce changes in the circadian rhythms, leading also to the appearance of a food-entrained oscillator. The present study was designed to establish if the alterations of the circadian rhythms induced by timed hypocaloric food restriction are accompanied by structural changes in the SCN. Two groups of adult rats, both maintained on 12-h light/12-h dark cycles, were used; in one group, animals had permanent free access to food, whereas in the other they were subjected to a restricted hypocaloric early morning feeding during 7 months. Using stereological techniques and in situ hybridization, we have examined the structure of the SCN and the synthesis and expression of vasopressin (AVP) and vasoactive intestinal peptide (VIP). The volume of the SCN and the total number of neurons did not vary between the two groups. However, the total number of AVP- and VIP-immunoreactive neurons and the AVP and VIP mRNA levels were significantly decreased in timed hypocaloric food-restricted animals. The results ...Continue Reading

References

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Aug 23, 2002·Behavioural Brain Research·Nikolai V LukoyanovJosé P Andrade
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Etienne Challet, Paul Pévet
Jun 24, 2003·Biological Chemistry·Etienne ChalletPaul Pévet

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Citations

Feb 23, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Etienne Challet
Jun 22, 2010·Cell and Tissue Research·Etienne Challet, Jorge Mendoza
Aug 30, 2012·Chronobiology International·Pascale Bouchard-Cannon, Hai-Ying M Cheng
Oct 30, 2009·The European Journal of Neuroscience·M Verwey, S Amir
Jun 23, 2011·Neuroscience and Biobehavioral Reviews·I D BlumA Abizaid

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