PMID: 8950526Sep 1, 1996Paper

Timed killing kinetic studies of the interaction between ciprofloxacin and beta-lactams against gram-negative bacilli

Diagnostic Microbiology and Infectious Disease
J K PohlmanJ A Washington

Abstract

Timed killing kinetic studies were performed with ciprofloxacin in combination with aztreonam, ceftazidime, piperacillin/tazobactam, and ticarcillin/clavulanic acid against three isolates each of Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, and Pseudomonas aeruginosa. Each antimicrobial agent in the combination was tested at its MIC and at one-half and one-quarter of its MIC. Colony counts were determined at 0, 3, 5, and 7 hours. Synergy occurred most frequently at 7 hours and, when present, was most likely to occur when ciprofloxacin and the beta-lactam were tested at concentrations equal to their respective MICs. Synergy after 3 hours of incubation was not predictive of a synergestic interaction at 5 or 7 hours. Antagonism was noted in several instances, particularly when ciprofloxacin and the beta-lactam were combined at one-quarter of their respective MICs.

Citations

Jun 19, 2003·Diagnostic Microbiology and Infectious Disease·David S BurgessThomas C Hardin
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
Aug 4, 2004·The Lancet Infectious Diseases·Nasia SafdarDennis G Maki
Jul 20, 2010·Critical Care Medicine·Anand KumarUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
Jul 16, 2004·The Kaohsiung Journal of Medical Sciences·Yen-Hsu ChenTyen-Po Chen
Jun 3, 2015·Current Infectious Disease Reports·Stephen Y Liang, Anand Kumar

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