Abstract
Timed killing kinetic studies were performed with ciprofloxacin in combination with aztreonam, ceftazidime, piperacillin/tazobactam, and ticarcillin/clavulanic acid against three isolates each of Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, and Pseudomonas aeruginosa. Each antimicrobial agent in the combination was tested at its MIC and at one-half and one-quarter of its MIC. Colony counts were determined at 0, 3, 5, and 7 hours. Synergy occurred most frequently at 7 hours and, when present, was most likely to occur when ciprofloxacin and the beta-lactam were tested at concentrations equal to their respective MICs. Synergy after 3 hours of incubation was not predictive of a synergestic interaction at 5 or 7 hours. Antagonism was noted in several instances, particularly when ciprofloxacin and the beta-lactam were combined at one-quarter of their respective MICs.
References
Dec 1, 1991·Antimicrobial Agents and Chemotherapy·C ChuardD P Lew
Sep 1, 1990·Antimicrobial Agents and Chemotherapy·C I BustamanteJ C Wade
Dec 1, 1985·The Journal of Antimicrobial Chemotherapy·G S Davies, J Cohen
Feb 1, 1986·European Journal of Clinical Microbiology·N X ChinH C Neu
Nov 1, 1988·Diagnostic Microbiology and Infectious Disease·R D Meyer, S Liu
Jan 1, 1988·The Journal of Antimicrobial Chemotherapy·E YourassowskyY Glupczynski
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·G J ForstallJ A Washington
Citations
Oct 12, 2000·Diagnostic Microbiology and Infectious Disease·D S Burgess, R W Hastings
Jun 19, 2003·Diagnostic Microbiology and Infectious Disease·David S BurgessThomas C Hardin
Nov 5, 2003·Diagnostic Microbiology and Infectious Disease·Helio S SaderRonald N Jones
Jan 1, 2003·International Journal of Antimicrobial Agents·W SongK M Lee
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
May 9, 2014·Future Microbiology·Matteo BassettiDavide Pecori
Nov 5, 2013·Virulence·Anand Kumar
Aug 4, 2004·The Lancet Infectious Diseases·Nasia SafdarDennis G Maki
Jun 22, 2010·Critical Care Medicine·Anand KumarDan Chateau
Jul 20, 2010·Critical Care Medicine·Anand KumarUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
Jul 16, 2004·The Kaohsiung Journal of Medical Sciences·Yen-Hsu ChenTyen-Po Chen
Jun 3, 2015·Current Infectious Disease Reports·Stephen Y Liang, Anand Kumar
Jan 26, 2006·Journal of Chemotherapy·H S SaderR N Jones