Timed motor tests can detect subtle motor dysfunction in early Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
C A HaaxmaM W I M Horstink

Abstract

Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration <or=2 years; dopa-naive) and 100 healthy, age-matched controls with eight simple TMTs based on aspects of (a) walking, (b) writing, (c) single and double-handed pegboard performance, (d) finger tapping, and (e) diadochokinesis. We evaluated the ability of individual and combined TMTs to discriminate patients from controls using ROC curves. Second, we investigated whether these TMTs could identify motor dysfunction of the clinically unaffected limb in 42 strictly hemiparkinsonian patients. The pegboard dexterity test had the best ROC curve (AUC 0.97; 95% sensitivity, 89% specificity) for patients versus controls. It retained reasonable accuracy when testing the clinically unaffected limb of hemiparkinsonian patients versus the mean of right and left-hand scores in controls (AUC 0.73). The pegboard dexterity test is a sensiti...Continue Reading

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Citations

Jun 30, 2012·Age and Ageing·Desiree Joy LanzinoJohn H Hollman
Aug 2, 2012·Journal of Neurologic Physical Therapy : JNPT·Desiree J LanzinoJohn H Hollman
Nov 2, 2013·Perceptual and Motor Skills·Kerry A HubelDavid L Woods
Feb 26, 2016·Cerebellum & Ataxias·Irene Pulido-ValdeolivasJavier Arpa
Jul 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Sebastian HeinzelDaniela Berg
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Mar 1, 2019·Frontiers in Aging Neuroscience·Markus A HobertSebastian Heinzel
Nov 13, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Tian WangJie Zhuang

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