TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells

Cancer Research
Taiwen LiX Shirley Liu

Abstract

Recent clinical successes of cancer immunotherapy necessitate the investigation of the interaction between malignant cells and the host immune system. However, elucidation of complex tumor-immune interactions presents major computational and experimental challenges. Here, we present Tumor Immune Estimation Resource (TIMER; cistrome.shinyapps.io/timer) to comprehensively investigate molecular characterization of tumor-immune interactions. Levels of six tumor-infiltrating immune subsets are precalculated for 10,897 tumors from 32 cancer types. TIMER provides 6 major analytic modules that allow users to interactively explore the associations between immune infiltrates and a wide spectrum of factors, including gene expression, clinical outcomes, somatic mutations, and somatic copy number alterations. TIMER provides a user-friendly web interface for dynamic analysis and visualization of these associations, which will be of broad utilities to cancer researchers. Cancer Res; 77(21); e108-10. ©2017 AACR.

References

Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Nov 15, 2012·Current Opinion in Oncology·Daniel MenendezMichael A Resnick
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
Jul 21, 2015·Nature Medicine·Andrew J GentlesAsh A Alizadeh
May 31, 2016·Nature Genetics·Bo LiX Shirley Liu
Jun 24, 2016·Journal of the National Cancer Institute·Michael D IglesiaBenjamin G Vincent
Jul 5, 2016·Nature Reviews. Genetics·Hubert HacklZlatko Trajanoski

❮ Previous
Next ❯

Citations

Sep 28, 2018·Personalized Medicine·Jin DengWeiming Zeng
Jun 12, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Amrendra MishraSubhashini Sadasivam
Jan 24, 2019·International Journal of Cancer. Journal International Du Cancer·Xue-Ling LiuLing-Hua Meng
Feb 21, 2019·International Journal of Cancer. Journal International Du Cancer·Jie-Gang YangYi-Fang Zhao
Mar 13, 2019·The Journal of Clinical Investigation·Takahiro KamiyaDario Campana
Jul 13, 2019·Journal of Cellular Biochemistry·Lianhao SongMing Chu
Jul 20, 2019·Cancer Biomarkers : Section a of Disease Markers·Liang ZhangWenlei Zhuo
Jan 14, 2020·Cancer Biomarkers : Section a of Disease Markers·Yong-Yao GuSheng-Hua Li
Feb 23, 2020·Nature Communications·Chia-Chin WuP Andrew Futreal
Aug 30, 2019·Genome Medicine·Megan M RichtersMalachi Griffith
May 23, 2020·Nucleic Acids Research·Taiwen LiX Shirley Liu
May 7, 2020·Cancers·Nur AzizAnd Jae Youl Cho
Jun 13, 2020·The Journal of International Medical Research·Xueying CaiAn Su
Dec 19, 2019·Pathology Oncology Research : POR·Chaoran YuMinhua Zheng
Jun 26, 2020·Technology in Cancer Research & Treatment·Haoyuan CaoWei Wang
Aug 5, 2020·Biomarkers in Medicine·Jing QuanQi Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.