Timing and regulation of trkB and BDNF mRNA expression in placode-derived sensory neurons and their targets

The European Journal of Neuroscience
M RobinsonA M Davies

Abstract

The sensory neurons of the vestibular and nodose ganglia of the chicken embryo have nearby and distant targets, respectively. In vitro studies have shown that these neurons survive independently of neurotrophins when their axons are growing to their targets and become dependent on brain-derived neurotrophic factor (BDNF) for survival when their axons reach the vicinity of their targets. Although the timing of BDNF dependence is principally controlled by an intrinsic timing mechanism in the neurons, the onset of dependence can be accelerated by BDNF exposure toward the end of the phase of neurotrophin independence. We have used quantitative reverse transcription/polymerase chain reaction to study the expression of transcripts coding for BDNF and the catalytic isoform of its receptor tyrosine kinase, TrkB, in these neurons and their targets at different stages of development. We show that the peripheral and central target tissues of these neurons express BDNF mRNA prior to the arrival of sensory axons. Vestibular neurons express trkB mRNA before nodose neurons, which accords with the earlier response of vestibular neurons to BDNF. In culture, early nodose neurons start expressing trkB mRNA after 36 h incubation, which is 36 h bef...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS P Squinto
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·U PirvolaM Saarma
Jan 1, 1992·DNA Sequence : the Journal of DNA Sequencing and Mapping·P C MaisonpierreG D Yancopoulos
Mar 25, 1991·Nucleic Acids Research·M C LebeauS Catsicas
Jul 1, 1988·Trends in Neurosciences·E M JohnsonP S DiStefano
Apr 1, 1983·The American Journal of Anatomy·A D'Amico-Martel, D M Noden
Apr 1, 1982·The American Journal of Anatomy·A D'Amico-Martel
Jul 1, 1995·Current Biology : CB·A M Davies, E M Wright
Nov 1, 1994·Journal of Neurobiology·A M Davies
May 1, 1994·The European Journal of Neuroscience·J S RudgeN Y Ip
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J FrisénD Lindholm
Oct 1, 1992·The European Journal of Neuroscience·Patrik ErnforsHåkan Persson
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Aug 27, 2013·Experimental Cell Research·Maddalena RavasiGiovanni Tredici
May 15, 2002·Life Sciences·Haruhiro SaitoYoshihiro Ishikawa
Jul 24, 1998·Brain Research. Molecular Brain Research·R BovaG G Zucconi
Jun 18, 2003·Respiratory Physiology & Neurobiology·David M Katz
Jun 14, 2001·The European Journal of Neuroscience·M Z GuimarãesF G De Mello
Jun 8, 2002·Annual Review of Neuroscience·Edwin W Rubel, Bernd Fritzsch
May 30, 2009·Cell Transplantation·Rabindra P SinghFeng C Zhou
Dec 6, 2019·Experimental Brain Research·Lianlian LiRuijin Huang
Feb 19, 2000·Journal of Neuroscience Research·K HuberA M Davies

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