Timing But Not Patterns of Recurrence Is Different Between Node-negative and Node-positive Resected Pancreatic Cancer.

Annals of Surgery
Kim C HonselmannCristina R Ferrone

Abstract

Our aim was to evaluate recurrence patterns of surgically resected PDAC patients with negative (pN0) or positive (pN1) lymph nodes. Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer death by 2030. This is mostly due to early local and distant metastasis, even after surgical resection. Knowledge about patterns of recurrence in different patient populations could offer new therapeutic avenues. Clinicopathologic data were collected for 546 patients who underwent resection of their PDAC between 2005 and 2016 from 2 tertiary university centers. Patients were divided into an upfront resection group (n = 394) and a neoadjuvant group (n = 152). Tumor recurrence was significantly less common in pN0 patients as compared with pN1 patients, (upfront surgery: 55% vs. 77%, P < 0.001 and 64% vs. 78%, P = 0.040 in the neoadjuvant group). In addition, time to recurrence was significantly longer in pN0 versus pN1 patients in the upfront resected patients (median 16 mo pN0 vs. 10 mo pN1 P < 0.001), and the neoadjuvant group (pN0 21 mo vs. 11 mo pN1, P < 0.001). Of the patients who recurred, 62% presented with distant metastases (63% of pN0 and 62% of pN1, P = 0.553), 24% with local disease (27% of p...Continue Reading

References

Nov 21, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Cristina R FerronePeter J Allen
May 7, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hartwig RiedigerFrank Makowiec
Apr 28, 2010·International Journal of Radiation Oncology, Biology, Physics·Theodore S HongCarlos Fernandez-Del Castillo
Jul 6, 2012·Surgery·Cristina R FerroneAndrew L Warshaw
Dec 12, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nakul P ValsangkarSarah P Thayer
Jan 8, 2016·Langenbeck's Archives of Surgery·Hryhoriy LapshynDirk Bausch
Jul 10, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M ItchinsS Clarke

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Citations

Apr 10, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Chen LiuGuopei Luo
Dec 15, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hryhoriy LapshynLouisa Bolm
May 4, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Stefano CrippaMassimo Falconi
May 19, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jia-Chen GeDian-Rong Xiu

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