Timing-dependent effects of restraint stress on eosinophilic airway inflammation in mice

Neuroimmunomodulation
S Kumlien GeorénP Stierna

Abstract

Chronic stress has been proposed to aggravate allergic inflammation, whereas acute stress may have functional beneficial effects. The aim of this study was to investigate the influence of timing of single short restraint stress (RST) in a model of eosinophilic airway inflammation. The airways of ovalbumin (OVA)-sensitized mice were exposed to an intranasal OVA challenge. RST was applied in two different ways; either 2 h before (pre-stress) or after (post-stress) the OVA challenge, respectively, or as a combination of stress before and after (double-stress) the OVA challenge. One group of mice was also treated with metyrapone (ME) prior to a pre-stress challenge. The inflammatory cell response was evaluated in bronchoalveolar lavage fluid (BALF), lung and nasal tissue, as well as bone marrow. RST applied prior to the OVA challenge (pre-stress) inhibited OVA-induced airway inflammation in BALF and lung tissue, and reduced nasal histopathology compared to unstressed mice. Given as post-stress or double-stress, RST did not affect the inflammation in BALF, lungs or nasal tissue. Pre-treatment with ME prevented the pre-challenge stress evoked decrease in inflammation in BALF and lungs. Effects of RST on eosinophilic airway inflammati...Continue Reading

Citations

Mar 24, 2017·Inhalation Toxicology·Nour A Al-SawalhaNidal A Qinna
May 20, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert LimLester Kobzik
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology

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