Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models

PloS One
Yatu GuoKanxing Zhao

Abstract

Visual deprivation during the critical period induces long-lasting changes in cortical circuitry by adaptively modifying neuro-transmission and synaptic connectivity at synapses. Spike timing-dependent plasticity (STDP) is considered a strong candidate for experience-dependent changes. However, the visual deprivation forms that affect timing-dependent long-term potentiation(LTP) and long-term depression(LTD) remain unclear. Here, we demonstrated the temporal window changes of tLTP and tLTD, elicited by coincidental pre- and post-synaptic firing, following different modes of 6-day visual deprivation. Markedly broader temporal windows were found in robust tLTP and tLTD in the V1M of the deprived visual cortex in mice after 6-day MD and DE. The underlying mechanism for the changes seen with visual deprivation in juvenile mice using 6 days of dark exposure or monocular lid suture involves an increased fraction of NR2b-containing NMDAR and the consequent prolongation of NMDAR-mediated response duration. Moreover, a decrease in NR2A protein expression at the synapse is attributable to the reduction of the NR2A/2B ratio in the deprived cortex.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A G Leventhal, H V Hirsch
Feb 1, 1986·Brain Research·M CarlsonT N Wiesel
Aug 16, 1994·European Journal of Pharmacology·D J Laurie, P H Seeburg
Nov 15, 1996·Science·L C Katz, C J Shatz
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·E M QuinlanM F Bear
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Harel Z ShouvalLeon N Cooper
Aug 6, 2002·Neuron·Andres Barria, Roberto Malinow
Feb 11, 2003·Nature Neuroscience·Cara B AllenDaniel E Feldman
Jul 10, 2003·Trends in Neurosciences·Nicoletta BerardiLamberto Maffei
Apr 6, 2004·Nature Neuroscience·Tansu CelikelDaniel E Feldman
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Bo LiuEdward G Jones
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Susanna B MierauOle Paulsen
Mar 19, 2005·Science·Helmut J Koester, Daniel Johnston
Dec 2, 2005·Journal of Neurophysiology·Robert C FroemkeYang Dan
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hai-Yan HeElizabeth M Quinlan
May 6, 2006·The Journal of Physiology·Björn M KampaGreg J Stuart
Aug 25, 2006·Nature·Arianna MaffeiGina G Turrigiano
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas Nevian, Bert Sakmann
Feb 14, 2007·Neuron·Benjamin D PhilpotMark F Bear
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebekah CorlewBenjamin D Philpot
Feb 16, 2008·Annual Review of Neuroscience·Natalia Caporale, Yang Dan
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arianna Maffei, Gina G Turrigiano
Jun 3, 2008·Nature Neuroscience·Antonio Rodríguez-Moreno, Ole Paulsen
Jul 25, 2008·Journal of Neurophysiology·Brian S BlaisMark F Bear
Aug 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniela TropeaMriganka Sur
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sam F Cooke, Mark F Bear
Jan 1, 2010·Frontiers in Synaptic Neuroscience·Rylan S LarsenBenjamin D Philpot

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Citations

Nov 17, 2020·Frontiers in Cellular Neuroscience·Justin L BalsorKathryn M Murphy
Dec 7, 2021·Frontiers in Neuroscience·Justin L BalsorKathryn M Murphy

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