Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction

Biomaterials
Tomo YoshizumiWilliam R Wagner

Abstract

Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infarction responses including functional loss, inflammation and fibrosis with distinct time dependent patterns. Changes in LV geometry and contractile function were followed by longitudinal echocardiography for 10 w post-MI. While all injection times positively affected LV function and wall thickness, the 3D group gave better functional outcomes than the other injection times and also exhibited more local vascularization and less inflammatory markers than the earlier injection time. The results indicate an important role for injection timing in t...Continue Reading

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Citations

May 27, 2016·Biomaterials Research·Zhaobo Fan, Jianjun Guan
Mar 31, 2018·Advanced Materials·Joshua E MealyJason A Burdick
Oct 13, 2016·Circulation. Cardiovascular Interventions·Christopher B RodellRobert C Gorman
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Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanxin HanWei Jin
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Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Wenguang Li
Jun 8, 2021·JACC. Basic to Translational Science·Lindemberg M Silveira-FilhoWilliam R Wagner

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