journal cover

Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development

Immunological Reviews

Apr 1, 1987

D AllenM Siekevitz

PMID: 3298009

Abstract

While somatic antibody mutants are rare in the preimmune repertoire and in primary immune responses, they dominate secondary and hyperimmune responses. We present evidence that somatic hypermutation is restricted to a particular pathway of B-cell differentiation in which distinct sets o...read more

Mentioned in this Paper

Immune Response
Biochemical Pathway
CDR1 gene
Somatic Mutation
Binding Sites, Antibody
Mutagenesis, Site-Directed
SLC3A2 gene
CDR1 protein, human
Immunoglobulin Isotypes
Cell Differentiation Process
Paper Details
References
  • References40
  • Citations123
1234
  • References40
  • Citations123
12345...

Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development

Immunological Reviews

Apr 1, 1987

D AllenM Siekevitz

PMID: 3298009

DOI:

Abstract

While somatic antibody mutants are rare in the preimmune repertoire and in primary immune responses, they dominate secondary and hyperimmune responses. We present evidence that somatic hypermutation is restricted to a particular pathway of B-cell differentiation in which distinct sets o...read more

Mentioned in this Paper

Immune Response
Biochemical Pathway
CDR1 gene
Somatic Mutation
Binding Sites, Antibody
Mutagenesis, Site-Directed
SLC3A2 gene
CDR1 protein, human
Immunoglobulin Isotypes
Cell Differentiation Process
Paper Details
References
  • References40
  • Citations123
1234
  • References40
  • Citations123
12345...
/papers/timing-genetic-requirements-and-functional/3298009