Timing modulates the effect of sleep loss on glucose homeostasis

The Journal of Clinical Endocrinology and Metabolism
Britta WilmsSebastian M Schmid

Abstract

Chronobiological factors may modulate the impact of sleep loss on glucose homeostasis. However, these interactions have not been systematically assessed in humans. To assess effect of sleep loss during the late vs. early night on glucose homeostasis. Fifteen normal-weight men participated in three conditions of a randomized, balanced cross-over study comprising two conditions with shortened sleep (4 h of sleep during the first or the second night-half, respectively) and a control condition with 8 h of sleep. Glucose, insulin, cortisol, and glucagon were measured. Insulin sensitivity and secretion were assessed by a botnia clamp. Sleep loss compared to regular sleep duration reduced insulin sensitivity (M-Value; P=0.031) irrespective of early- or late-night timing (p=0.691). The Disposition Index, i.e., the ß-cell response adjusted for insulin sensitivity, also tended to be impaired by short sleep (p=0.056), but not by sleep timing (p=0.543). In contrast, sleep loss in the second, but not the first night-half induced reductions in morning glucagon and cortisol (p<0.031) followed by a transient increase in cortisol (p<0.044). While sleep deprivation acutely reduces insulin sensitivity irrespective of its nocturnal timing, sleep l...Continue Reading

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Citations

Feb 9, 2020·Nutrients·María Fernanda Zerón-RugerioMaria Izquierdo-Pulido
Aug 5, 2020·FEBS Letters·Anna-Marie FingerAchim Kramer
Nov 2, 2019·The Chinese Journal of Physiology·Oktay KayaLevent Ozturk
May 2, 2019·The Journal of Clinical Endocrinology and Metabolism·Peter Y Liu
Sep 22, 2020·Sleep Medicine·Siaw Cheok Liew, Thidar Aung
Feb 17, 2021·Deutsche medizinische Wochenschrift·Henrik OsterSebastian M Schmid
Jan 31, 2020·Journal of Molecular Biology·Flore SinturelCharna Dibner
Apr 15, 2021·Primary Care Diabetes·Ranjit TiwariNguyen Tien Huy

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