Timing of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor initiation and allograft vasculopathy progression and outcomes in heart transplant recipients

ESC Heart Failure
Rabea AslehSudhir S Kushwaha

Abstract

Early studies from the 1990s have shown that statins improve survival and attenuate cardiac allograft vasculopathy (CAV). However, little contemporary data are available on the incremental benefit of statins with the current use of new-generation immunosuppressive agents and the use of coronary intravascular ultrasound for assessment of CAV. We sought to investigate the effect of early statin (ES) as compared with late statin (LS) initiation after heart transplantation (HT) on long-term CAV progression and clinical outcomes in a large contemporary HT cohort. We analysed a cohort of 409 adult HT recipients. CAV progression was assessed by serial coronary intravascular ultrasound volumetric measurements of the differences between baseline and last follow-up plaque volume (PV) and plaque index (PV/vessel volume ratio). CAV progression and clinical outcomes were compared between the ES (<2 years after HT) and the LS (>2 years after HT) groups. During a median follow-up of 8.2 years, ES resulted in significantly lower change (Δ) of plaque index (+3.8% ± 1.7% vs. +8.2% ± 3.6%; P = 0.0008) and PV (+0.8 ± 0.3 vs. +1.9 ± 1.2; P = 0.045) compared with LS group. In a Cox proportional hazards regression model and after adjustment for basel...Continue Reading

References

May 11, 1992·Journal of the American College of Cardiology·C M BallantyneA M Gotto
Sep 7, 1995·The New England Journal of Medicine·J A KobashigawaG A Cogert
Jun 1, 2000·Transplantation·H HölschermannW Haberbosch
Nov 13, 2002·Journal of the American College of Cardiology·Mandeep R MehraCarl J Lavie
Aug 17, 2004·American Heart Journal·Kenneth C BilchickRoger S Blumenthal
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon A KobashigawaLawrence Yeatman
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sudhir S KushwahaBrooks S Edwards
Jan 3, 2006·Transplantation Proceedings·R Marzoa-RivasA Castro-Beiras
Oct 14, 2006·Circulation Research·Maziar RahmaniBruce M McManus
Jul 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraPatricia A Uber
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines
Oct 12, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundJosef Stehlik
Feb 9, 2018·Journal of the American College of Cardiology·Rabea AslehSudhir S Kushwaha

❮ Previous
Next ❯

Citations

Mar 19, 2019·Transplantation·Andriana P Nikolova, Jon A Kobashigawa
Jun 27, 2019·Transplantation·Andriana P Nikolova, Jon A Kobashigawa

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
percutaneous coronary angioplasty

Software Mentioned

SPSS
JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Rabea AslehSudhir S Kushwaha
Journal of the American College of Cardiology
Rabea AslehSudhir S Kushwaha
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Rabea AslehSudhir S Kushwaha
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
S M HollenbergM R Costanzo
© 2022 Meta ULC. All rights reserved