Timing of adjuvant surgical oophorectomy in the menstrual cycle and disease-free and overall survival in premenopausal women with operable breast cancer

Journal of the National Cancer Institute
Richard R LoveDavid Jarjoura

Abstract

For women with hormone receptor-positive, operable breast cancer, surgical oophorectomy plus tamoxifen is an effective adjuvant therapy. We conducted a phase III randomized clinical trial to test the hypothesis that oophorectomy surgery performed during the luteal phase of the menstrual cycle was associated with better outcomes. Seven hundred forty premenopausal women entered a clinical trial in which those women estimated not to be in the luteal phase of their menstrual cycle for the next one to six days (n = 509) were randomly assigned to receive treatment with surgical oophorectomy either delayed to be during a five-day window in the history-estimated midluteal phase of the menstrual cycles, or in the next one to six days. Women who were estimated to be in the luteal phase of the menstrual cycle for the next one to six days (n = 231) were excluded from random assignment and received immediate surgical treatments. All patients began tamoxifen within 6 days of surgery and continued this for 5 years. Kaplan-Meier methods, the log-rank test, and multivariable Cox regression models were used to assess differences in five-year disease-free survival (DFS) between the groups. All statistical tests were two-sided. The randomized midl...Continue Reading

References

May 2, 2002·Journal of the National Cancer Institute·Richard R LoveDavid L DeMets
Oct 3, 2002·Journal of the National Cancer Institute·Richard R Love, John Philips
Dec 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard R LoveDavid Jarjoura
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clive S GrantLynn C Hartmann
Apr 16, 2010·Clinical Trials : Journal of the Society for Clinical Trials·Erinn M Hade Lai Wei
Feb 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel F Hayes
Feb 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan S CoatesAron Goldhirsch

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Citations

Apr 14, 2016·Critical Reviews in Oncology/hematology·Hillary Klonoff-CohenGeorg E Matt
Mar 26, 2016·Breast Cancer Research and Treatment·Richard R Love, Susan M Love
Apr 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Richard R LoveDavid Jarjoura
Jun 23, 2016·The Breast : Official Journal of the European Society of Mastology·Richard R Love
Sep 1, 2015·World Journal of Biological Chemistry·Franco LumachiStefano Mm Basso
Feb 12, 2017·Current Treatment Options in Oncology·Matteo LambertiniEvandro de Azambuja
Oct 26, 2018·The New England Journal of Medicine·Rowan T Chlebowski, Kathy Pan
Jan 14, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher D HartAngelo Di Leo

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