Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction.

Circulation. Cardiovascular Imaging
Rutger-Jan SwijnenburgJoseph C Wu

Abstract

Despite ongoing clinical trials, the optimal time for delivery of bone marrow mononuclear cells (BMCs) after myocardial infarction is unclear. We compared the viability and effects of transplanted BMCs on cardiac function in the acute and subacute inflammatory phases of myocardial infarction. The time course of acute inflammatory cell infiltration was quantified by FACS analysis of enzymatically digested hearts of FVB mice (n=12) after left anterior descending artery ligation. Mac-1(+)Gr-1(high) neutrophil infiltration peaked at day 4. BMCs were harvested from transgenic FVB mice expressing firefly luciferase (Fluc) and green fluorescent protein (GFP). Afterward, 2.5x10(6) BMCs were injected into the left ventricle of wild-type FVB mice either immediately (acute BMC) or 7 days (subacute BMC) after myocardial infarction, or after a sham procedure (n=8 per group). In vivo bioluminescence imaging showed an early signal increase in both BMC groups at day 7, followed by a nonsignificant trend (P=0.203) toward improved BMC survival in the subacute BMC group that persisted until the bioluminescence imaging signal reached <0.01) and 6 weeks (both BMC groups versus saline; P<0.05) but no significant differences between the 2 BMC groups....Continue Reading

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Citations

Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Patricia E de AlmeidaJoseph C Wu
Oct 29, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Ahmad Y SheikhJoseph C Wu
Oct 1, 2011·Circulation Research·Patricia K NguyenJoseph C Wu
Feb 2, 2011·Circulation·Ian Y Chen, Joseph C Wu
Aug 21, 2013·PloS One·Xinrui YanSanjiv S Gambhir
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joseph C WuDara L Kraitchman
Jun 4, 2011·Cardiovascular Drugs and Therapy·Drew KuraitisErik J Suuronen
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Aug 6, 2015·ACS Nano·Katherine MargulisRichard N Zare
Apr 8, 2014·Cell Stem Cell·Patricia K NguyenJoseph C Wu
Nov 13, 2010·JACC. Cardiovascular Imaging·Eric A Osborn, Farouc A Jaffer
Jan 14, 2012·JACC. Cardiovascular Imaging·Koen E A van der BogtJoseph C Wu
May 7, 2013·JACC. Cardiovascular Imaging·Peter J PsaltisMartin Rodriguez-Porcel
Oct 8, 2014·Cell Transplantation·Federico FranchiMartin Rodriguez-Porcel
Dec 17, 2010·World Journal of Cardiology·Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho
Jun 25, 2016·Circulation Research·Ian Y Chen, Joseph C Wu
Jan 5, 2014·Circulation Research·Elena MatsaJoseph C Wu
Aug 21, 2013·Circulation Research·Sang-Ging Ong, Joseph C Wu
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Aug 27, 2019·Frontiers in Cardiovascular Medicine·Malebogo NgoepeThomas Franz

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