PMID: 3320528Dec 1, 1987Paper

Timing of cyclosporine administration in patients with delayed graft function

The Journal of Surgical Research
A J MatasF J Veith

Abstract

Cyclosporine in renal transplant recipients with delayed graft function (DGF) has been reported to decrease graft survival and prolong both DGF and hospitalization. In some centers, antilymphocyte globulin (ALG) has been used perioperatively to obviate these problems, but ALG is associated with increased viral infections. In this study, first cadaver transplant recipients with a fall in serum creatinine level of greater than or equal to 30% in the first 24 hr were started on prednisone (P) and cyclosporine (Group 1, n = 18). Those whose creatinine level did not fall were started on P and azathioprine (Group 2, n = 23) and switched to P and cyclosporine when serum creatinine fell 30%. One-year patient survival was 98%. One-year graft survival was 83% for both Groups 1 and 2 (NS). Results were compared to historical controls with DGF who received P and cyclosporine (Group 3, n = 19). Patients with DGF and requiring dialysis had fewer dialyses (P less than 0.05) and a shorter hospital stay (P less than 0.05) if started on azathioprine, as compared to those started on cyclosporine. Patients with DGF had a higher serum creatinine at 12 months than those with immediate function (P less than 0.05). We conclude that withholding cyclosp...Continue Reading

References

Mar 1, 1980·Transplantation·D BrophyC M Kjellstrand
Mar 1, 1982·The Journal of Surgical Research·A J MatasJ S Najarian

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Citations

Sep 22, 2009·Transplantation Proceedings·H T KhosroshahiM Ardalan
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N KamarL Rostaing
Jul 24, 2008·Clinical Transplantation·Jason MooreRichard Borrows

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