Timing of death in children referred for intensive care with severe sepsis: implications for interventional studies

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Mirjana CvetkovicMark J Peters

Abstract

Early deaths in pediatric sepsis may limit the impact of therapies that can only be provided on PICUs. By introducing selection and survivorship biases, these very early deaths may also undermine the results of trials that employ standard consent procedures. We hypothesized that: 1) the majority of deaths in children with severe sepsis occur very early, within 24 hours of referral to PICU; and 2) a significant proportion of deaths occur before PICU admission. We studied consecutive referrals of newborns through to 16 years of age, between 2005 and 2011 to the Children's Acute Transport Service, the North Thames regional pediatric intensive care transport service, with a working diagnosis of "sepsis," "severe sepsis," "meningococcal sepsis," or "septic shock." The primary outcome measure was the proportion of deaths within 24 hours of referral. Survival distributions of previously healthy children were compared with those with significant comorbidities. Thirteen thousand four hundred and nine referrals were made to Children's Acute Transport Service, of whom 703 (5%) met inclusion criteria. Data on survival to 1 year were available in 627 of 703 patients (89%). One hundred thirty children (130/627; 21%; 95% CI, 18-24%) died in t...Continue Reading

References

Jul 16, 1997·JAMA : the Journal of the American Medical Association·K E SandsUNKNOWN Academic Medical Center Consortium Sepsis Project Working Group
May 18, 1999·Archives of Disease in Childhood·A J PollardM Levin
Dec 1, 2000·Critical Care Medicine·K KloucheT Kamohara
Oct 23, 2001·Archives of Disease in Childhood·R BooyUNKNOWN Meningococcal Research Group
Nov 16, 2002·American Journal of Respiratory and Critical Care Medicine·R Scott WatsonDerek C Angus
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Francis LeclercJacques Lacroix
Mar 30, 2005·Lancet·Jennifer BryceUNKNOWN WHO Child Health Epidemiology Reference Group
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·R Scott Watson, Joseph A Carcillo
Mar 8, 2006·Archives of Pediatrics & Adolescent Medicine·Derek TaiJames G Wright
Mar 14, 2007·Lancet·Simon NadelUNKNOWN REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group
May 2, 2007·Journal of Medical Ethics·Padmanabhan RamnarayanChristine Pierce
Mar 29, 2008·Intensive Care Medicine·Mark J Peters, Joe Brierley
May 27, 2008·Intensive Care Medicine·Andrea WolflerUNKNOWN Italian Pediatric Sepsis Study (SISPe) group
Jan 10, 2009·Archives of Disease in Childhood·D P InwaldUNKNOWN Paediatric Intensive Care Society Study Group (PICS-SG)
Aug 5, 2011·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Kana Ram JatVinod K Gupta
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Mar 19, 2013·BMC Medicine·Kathryn MaitlandUNKNOWN FEAST trial group
Jul 3, 2013·Intensive Care Medicine·Akash DeepJoe Brierley
Jul 31, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanR Scott Watson
Mar 19, 2014·The New England Journal of Medicine·Donald M YealyDerek C Angus
Apr 9, 2014·Pediatrics·Raina PaulMark I Neuman

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Citations

Oct 6, 2016·Frontiers in Immunology·Samira AsgariUNKNOWN Swiss Pediatric Sepsis Study
May 27, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissJennifer Muszynski
Aug 11, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Luregn J Schlapbach
Sep 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Elizabeth Y Killien, R Scott Watson
Jul 13, 2018·Pediatric Annals·Edward E Conway
Aug 9, 2018·Archives of Disease in Childhood·David Philip InwaldUNKNOWN PERUKI (Paediatric Emergency Research in the UK and Ireland) and PICS SG (Paediatric Intensive Care Society Study Group)
Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
Jul 25, 2019·Current Opinion in Infectious Diseases·Luregn J Schlapbach
Apr 29, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·John S GiulianoUNKNOWN Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Netw
Oct 18, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Julie C FitzgeraldNiranjan Kissoon
Jun 17, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lexa K MurphyJerry Zimmerman
Oct 7, 2016·Intensive Care Medicine·Luc MorinUNKNOWN ESPNIC Refractory Septic Shock Definition Taskforce the Infection Systemic Inflammation Sepsis section of ESPNIC
Dec 30, 2017·Intensive Care Medicine·Scott L Weiss, Mark J Peters
Oct 16, 2018·Frontiers in Immunology·Gu-Lung LinAndrew J Pollard
Jan 14, 2020·International Journal of Pediatrics·Varsha Vekaria-HiraniIdris N Chipkophe
Jun 4, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jerry J Zimmerman
Feb 22, 2017·Intensive Care Medicine·Luregn J SchlapbachUNKNOWN Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and Australian & N
May 28, 2019·Frontiers in Pediatrics·Amanda HarleyLuregn J Schlapbach
Jan 1, 2020·Critical Care : the Official Journal of the Critical Care Forum·Luregn J SchlapbachUNKNOWN Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and the Australian
Nov 22, 2015·Critical Care : the Official Journal of the Critical Care Forum·Samiran Ray, Mark J Peters
Mar 21, 2017·Intensive Care Medicine·Mark J PetersJacques Lacroix
Mar 17, 2016·Current Opinion in Pediatrics·Brittany MathiasShawn D Larson
Nov 5, 2020·Journal of the American College of Emergency Physicians Open·Andrea T CruzLuregn J Schlapbach
Feb 14, 2021·The American Journal of Emergency Medicine·Emily HegamyerAndrew D Depiero
Sep 1, 2018·The Lancet Child & Adolescent Health·Philipp K A AgyemanUNKNOWN Swiss Pediatric Sepsis Study
Mar 28, 2021·British Dental Journal·Manas DaveNeil Patel
Feb 17, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·K Taneille JohnsonSrinivas Murthy
Apr 2, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissFran Balamuth

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