Timing of erythropoietin modified mesenchymal stromal cell transplantation for the treatment of experimental bronchopulmonary dysplasia

Journal of Cellular and Molecular Medicine
Zhao-Hua ZhangYun Luan

Abstract

The aim of this study is to optimize the timing of erythropoietin gene modified mesenchymal stem cells (EPO-MSCs) transplantation for bronchopulmonary dysplasia (BPD). Three weeks post-operation, the results indicated that the damage of airway structure and apoptosis were significantly decreased, the proliferation was increased in three EPO-MSCs transplantation groups as compared with BPD mice. Moreover, the inflammation cytokines were improvement in early EPO-MSCs injection mice than in BPD mice, but there was no significant difference between late injection and BPD groups. Furthermore, the protein expression ratio of p-p38/p38MAPK was down-regulation in early mice but not in late transplantation mice. Our findings suggest that EPO-MSCs maybe attenuate BPD injury in early than in late administration by inhibiting inflammation response through down-regulation of the p38MAPK signalling pathway.

References

Oct 15, 2003·Free Radical Biology & Medicine·John RomashkoLin L Mantell
Apr 26, 2006·Proceedings of the American Thoracic Society·Daniel J WeissDarwin J Prockop
Feb 14, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kristen A TropeaCarla F Kim
Jul 8, 2017·Journal of Cellular Biochemistry·Xin-Peng HanChang-Gui Wu
Aug 31, 2017·American Journal of Respiratory and Critical Care Medicine·Gareth R WillisStella Kourembanas

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Citations

Jun 28, 2019·Expert Review of Respiratory Medicine·Emma Williams, Anne Greenough
Dec 14, 2019·Current Opinion in Pediatrics·Amélie Collins
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty

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