PMID: 2498465Jul 1, 1989Paper

Timing of expression of tau and its encoding mRNAs in the developing cerebral neocortex and cerebellum of the mouse

Journal of Neurochemistry
G ManginJ Nunez

Abstract

The expression of tau mRNA and of the corresponding encoded protein variants was studied during postnatal development in two brain regions differing in their timing of differentiation: the cerebral neocortex and the cerebellum. (a) The expression of tau mRNA was different in the two regions. Maximal contents were found at early stages in the cerebral neocortex, with a 10-fold decrease at later stages. In the cerebellum, two peaks of tau mRNA were observed soon after birth and in adulthood, with minimal values at postnatal day 6. (b) The expression of total tau proteins was similar to that of their encoding mRNAs in the cerebral neocortex, i.e., high concentrations after birth and low contents at later stages. In contrast, two peaks of tau proteins were observed in the cerebellum: the first perinatally and the second with a maximum at postnatal day 15. (c) Both in the cerebral neocortex and especially in the cerebellum, increasing concentrations of mature tau variants were expressed at late developmental stages, i.e., when total tau protein contents were decreased. In conclusion, the fluctuations in expression of tau and of its encoding mRNA seen in the cerebellum seem to reflect differences in the timing of differentiation of t...Continue Reading

References

Oct 25, 1977·Journal of Molecular Biology·D W ClevelandM W Kirschner
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R D SlobodaP Greengard
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Nov 25, 1977·Journal of Molecular Biology·D B MurphyG G Borisy
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B Riederer, A Matus
Oct 1, 1985·The Journal of Cell Biology·L I BinderL I Rebhun
Dec 1, 1985·The Journal of Cell Biology·D CouchieJ Nunez
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M TytellR J Lasek
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L I BinderL I Rebhun
Dec 15, 1982·European Journal of Biochemistry·J FranconJ Nunez
Oct 1, 1980·Journal of Neurochemistry·A M LennonJ Nunez

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Citations

Sep 1, 1991·Neurochemical Research·J NunezA M Bridoux
Oct 20, 1999·Journal of Molecular Neuroscience : MN·S AronovI Ginzburg
Jan 1, 1990·Molecular Neurobiology·K S Kosik
Jan 14, 1994·Brain Research. Developmental Brain Research·M M Oblinger, S A Kost
Jun 27, 1995·Brain Research. Developmental Brain Research·S A Przyborski, M A Cambray-Deakin
Dec 1, 1992·Neurochemistry International·C Charrière-Bertrand, J Nunez
Apr 9, 2005·Trends in Cell Biology·Peter W Baas, Liang Qiang
Oct 1, 1991·The European Journal of Neuroscience·Beat M. Riederer, Giorgio M. Innocenti
Feb 6, 2017·EMBO Molecular Medicine·Julius BruchGünter U Höglinger
Aug 11, 2000·Brain Research·A Heicklen-KleinI Ginzburg

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