Timing of host feeding drives rhythms in parasite replication

PLoS Pathogens
Kimberley F PriorSarah E Reece

Abstract

Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment. Recent work shows that daily (circadian) rhythms also enable parasites to maximise fitness in the context of ecological interactions with their hosts. Because parasite rhythms matter for their fitness, understanding how they are regulated could lead to innovative ways to reduce the severity and spread of diseases. Here, we examine how host circadian rhythms influence rhythms in the asexual replication of malaria parasites. Asexual replication is responsible for the severity of malaria and fuels transmission of the disease, yet, how parasite rhythms are driven remains a mystery. We perturbed feeding rhythms of hosts by 12 hours (i.e. diurnal feeding in nocturnal mice) to desynchronise the host's peripheral oscillators from the central, light-entrained oscillator in the brain and their rhythmic outputs. We demonstrate that the rhythms of rodent malaria parasites in day-fed hosts become inverted relative to the rhythms of parasites in night-fed hosts. Our results reveal that the host's peripheral rhythms (associated with the timing of feeding and metabolism), but not rhythm...Continue Reading

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Citations

Dec 15, 2019·Immunology·Polly DowntonJulie E Gibbs
Aug 13, 2020·Proceedings. Biological Sciences·Aidan J O'DonnellSarah E Reece
Oct 5, 2018·Proceedings. Biological Sciences·Petra SchneiderSarah E Reece
Oct 5, 2018·Evolution Letters·Romain PigeaultSylvain Gandon
Oct 31, 2018·Nature Communications·Leen VandermostenPhilippe E Van den Steen
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Priscilla Carvalho CabralNicolas Cermakian
Apr 2, 2020·Frontiers in Cellular and Infection Microbiology·Ricardo Orozco-Solis, Lorena Aguilar-Arnal
Aug 22, 2018·Immunological Reviews·David S KhouryMiles P Davenport
May 16, 2020·Science·Filipa Rijo-FerreiraJoseph S Takahashi
Mar 20, 2019·Nature Ecology & Evolution·Mary L WestwoodSarah E Reece
Nov 26, 2020·Proceedings. Biological Sciences·J IsaïaR Pigeault
Feb 14, 2020·Cell Host & Microbe·Kimberley F PriorSarah E Reece
Jul 22, 2021·Evolution, Medicine, and Public Health·Alíz T Y OwolabiPetra Schneider

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

Home Cage Analysis system
R
multcomp R
CircWave

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