Timing of hypertonic saline inhalation for cystic fibrosis

The Cochrane Database of Systematic Reviews
Mark Elkins, Ruth Dentice

Abstract

Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. To determine whether the timing of hypertonic saline inhalation (in relation to airway clearance techniques or in relation to time of day) has an impact on its clinical efficacy in people with cystic fibrosis. We identified relevant randomised and quasi-randomised controlled trials from the Cochrane Cystic Fibrosis Trials Register, the Physiotherapy Evidence Database (PEDro), and international cystic fibrosis conference proceedings.Date of the last search of the Group's Cystic Fibrosis Trials Register: 6 December 2011. Any trial of hypertonic saline in people with cystic fibrosis where timing of inhalation was the randomised element in the study protocol with either: inhalation up to six hours before airway clearance techniques compared to inhalation during airway clearance techniques compared to inhalation up to six hours after airway clearance techniques; or morning compared to evening inhalation with any definition provided by the author. Both authors independently assessed the trials identified by the search for potential inclusion in the review. The search strategy ident...Continue Reading

Citations

Feb 2, 2017·The Cochrane Database of Systematic Reviews·Mark Elkins, Ruth Dentice
Feb 29, 2020·The Cochrane Database of Systematic Reviews·Mark Elkins, Ruth Dentice

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