Timing of Lymphedema After Treatment for Breast Cancer: When Are Patients Most At Risk?

International Journal of Radiation Oncology, Biology, Physics
Susan G R McDuffAlphonse G Taghian

Abstract

The purpose of the study was to determine when the risk of lymphedema is highest after treatment of breast cancer and which factors influence the time course of lymphedema development. Between 2005 and 2017, 2171 women (with 2266 at-risk arms) who received surgery for unilateral or bilateral breast cancer at our institution were enrolled. Perometry was used to objectively assess limb volume preoperatively, and lymphedema was defined as a ≥10% relative arm-volume increase arising >3 months postoperatively. Multivariable regression was used to uncover risk factors associated with lymphedema, the Cox proportional hazards model was used to calculate lymphedema incidence, and the semiannual hazard rate of lymphedema was calculated. With a median follow-up of 4 years, the overall estimated 5-year cumulative incidence of lymphedema was 13.7%. Significant factors associated with lymphedema on multivariable analysis were high preoperative body mass index, axillary lymph node dissection (ALND), and regional lymph node radiation (RLNR). Patients receiving ALND with RLNR experienced the highest 5-year rate of lymphedema (31.2%), followed by those receiving ALND without RLNR (24.6%) and sentinel lymph node biopsy with RLNR (12.2%). Overall,...Continue Reading

Citations

May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah A McLaughlinAlphonse Taghian
Mar 29, 2019·Breast Cancer Research and Treatment·Kayla M DaniellAlphonse G Taghian
Apr 10, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kathryn RyansLisa VanHoose
Jun 3, 2020·Cancer Medicine·Sheila H RidnerMary S Dietrich
Apr 30, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Xiaoyan LiuWei Xu
Aug 18, 2020·Journal of Cancer Survivorship : Research and Practice·Belinda ThompsonLouise A Koelmeyer
Jan 14, 2020·International Journal of Radiation Oncology, Biology, Physics·Julie A Bradley, Jennifer R Bellon
Nov 1, 2020·International Journal of Radiation Oncology, Biology, Physics·John BoyagesSheila H Ridner
May 1, 2021·International Journal of Environmental Research and Public Health·Inmaculada Carmen Lara-PalomoLucía Ortiz-Comino
Jun 10, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yan LinQiang Sun
Jun 28, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L M AbbassiY M Kirova
Jul 28, 2021·Cancer·Sacha A RobertsAlphonse G Taghian
Aug 10, 2021·Frontiers in Oncology·Runhong LeiRuijie Yang
Aug 19, 2021·Archives of Physical Medicine and Rehabilitation·Flávia Belavenuto RangonElaine Caldeira de Oliveira Guirro
Sep 4, 2021·Plastic and Reconstructive Surgery. Global Open·Mathias AlstrupVibeke E Hjortdal
Sep 11, 2021·Annals of Surgical Oncology·Yara W KassamaniAlphonse G Taghian
Sep 18, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Victor Domingos Lisita RosaRuffo Freitas-Junior
Sep 29, 2021·Archives of Plastic Surgery·Antonio Jorge ForteAlfredo Quiñones-Hinojosa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.