Timing of Onset of Adverse Cutaneous Reactions Associated With Programmed Cell Death Protein 1 Inhibitor Therapy

JAMA Dermatology
Leo L WangEmily Y Chu

Abstract

An increasing number of cutaneous adverse reactions resulting from use of programmed cell death protein 1 (PD-1) inhibitors have been described, but with relatively little focus to date on the timing of these reactions. To determine the timing of cutaneous drug reactions after initiation of PD-1 inhibitor therapy. This retrospective observational study included patients referred to an academic dermatology clinic by an oncologist from January 1, 2014, through February 28, 2018, with at least 1 skin biopsy specimen of a skin reaction associated with PD-1 inhibitor use. Participants were included if they had a biopsy-proven cutaneous reaction in response to a PD-1 inhibitor used alone or in combination with ipilimumab. All patients included in this study received pembrolizumab, nivolumab, or nivolumab with ipilimumab as immunotherapy for cancer. The main outcome measure was time to onset of biopsy-proven cutaneous reactions that occurred during or after use of pembrolizumab or nivolumab. A total of 17 patients (12 men, 5 women; mean [SD] age, 68.6 [11.1] years) were identified who presented with cutaneous adverse reactions associated with PD-1 inhibitor therapy; these reactions included lichenoid dermatitis, bullous pemphigoid, er...Continue Reading

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Citations

May 29, 2019·Current Opinion in Allergy and Clinical Immunology·Knut Brockow, Wolfgang Pfützner
Jul 25, 2019·Dermatologic Therapy·Carlos Cuenca-BarralesRicardo Ruiz-Villaverde
Jul 7, 2019·Journal for Immunotherapy of Cancer·Abdul Rafeh NaqashPaul R Walker
Feb 14, 2020·International Journal of Dermatology·Nolan J MaloneyScott Worswick
Nov 2, 2019·International Journal of Dermatology·Hasina MarediaManisha J Loss
Sep 15, 2020·JAMA : the Journal of the American Medical Association·Amy K BieberKristen Lo Sicco
Jul 20, 2019·International Journal of Clinical Oncology·Pooja H RambhiaMeg R Gerstenblith
Nov 30, 2019·International Journal of Dermatology·Hanjae LeeSeong Jin Jo
Jun 5, 2020·British Journal of Clinical Pharmacology·Paola Maria CutroneoGianluca Trifirò
Nov 23, 2020·Journal of Cancer Research and Clinical Oncology·Atsushi YamamotoYuzo Kodama
Dec 24, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Caroline E McCoach
Jan 24, 2021·The Australasian Journal of Dermatology·Adrian DiagoIsabel Abadías-Granado
Feb 26, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Masahide FukudoYoshinobu Ohsaki
Mar 4, 2021·The Journal of Dermatological Treatment·Thomas K LeShawn G Kwatra
Mar 4, 2021·Journal for Immunotherapy of Cancer·Thomas U MarronJennifer L Guerriero
Mar 7, 2021·Journal of Clinical Medicine·Hiroki HashimotoMasutaka Furue
May 21, 2021·BMC Gastroenterology·Stratigoula SakellariouIoanna Delladetsima
Jun 5, 2021·Critical Reviews in Oncology/hematology·Yiqun HanBinghe Xu
May 24, 2021·Surgical Pathology Clinics·Jonathan L CurryEmily Y Chu
Jul 18, 2021·Clinics in Dermatology·Robert T SpauldingJeffrey P Callen
Jul 22, 2021·International Journal of Dermatology·Catarina CorreiaPaulo Filipe
Nov 2, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan J SchneiderKathryn Bollin
Dec 24, 2021·Internal Medicine Journal·Terri ShihMohammad Sharaf

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