Timing of postpartum enoxaparin administration and severe postpartum hemorrhage

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Rachel A FreedmanJeffrey I Zwicker

Abstract

The appropriate time to restart anticoagulation in the postpartum period is not known. The purpose of the present study was to determine whether the timing of postpartum enoxaparin influences hemorrhagic outcomes. A total of 95 women were treated with peripartum enoxaparin and compared with 303 consecutive deliveries where anticoagulation was not administered. The overall rate of severe postpartum hemorrhage did not differ significantly for women treated with peripartum enoxaparin (4.2%) versus nonanticoagulated control individuals (2.0%, P = 0.40) nor for the subgroup of women who underwent vaginal delivery (3.6 versus 1.4%, P = 0.55) or cesarean section (5.1 versus 3.4%, P = 0.98). We did not observe any severe hemorrhagic events attributable to administration of postpartum enoxaparin. The first dose of enoxaparin was administered less than 24 h following delivery in 75% of vaginal deliveries and in 49% of cesarean sections where enoxaparin was given in the postpartum period. Two incisional hematomas were observed in the group of women who received enoxaparin within 24 h following cesarean section. Severe postpartum hemorrhage is an infrequent complication when enoxaparin is administered to hemostatically intact women between...Continue Reading

References

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Citations

Jul 15, 2015·Taiwanese Journal of Obstetrics & Gynecology·Maki GotoShingo Miyamoto
Apr 1, 2016·Current Opinion in Anaesthesiology·Vinod PatilDhuleep S Wijayatilake
Jun 26, 2018·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Sep 8, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Cetin KilicciSibel Mutlu
Sep 11, 2008·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Shunji SuzukiHidehiko Miyake
Nov 2, 2019·Obstetrical & Gynecological Survey·Chelsea M ClintonAndra H James
Jul 11, 2020·Obstetrics and Gynecology·Gabrielle Côté-PoirierNadine Sauvé
Jun 1, 2014·Obstetric Medicine·Erica Hz WangNesé Yuksel
Apr 27, 2021·Journal of Taibah University Medical Sciences·Yahya A MohzariRenad A Alshuraim

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