PMID: 6989436Mar 1, 1980Paper

Timing of pre-breakfast insulin injection and postprandial metabolic control in diabetic children

British Medical Journal
A L Kinmonth, J D Baum

Abstract

A peak period of hyperglycaemia in insulin-dependent diabetics occurs after breakfast. A randomised crossover study was performed on nine diabetic children at home to study the effect of varying the time of their morning mixed injection of Monotard and Actrapid insulin on this hyperglycaemic peak. Performing the study at home minimised the children's stress.After diabetic control had been improved children injected their insulin 30 minutes (early injection) or five minutes (late injection) before breakfast on two consecutive Saturday mornings. Blood samples were taken at 30-minute intervals over 3(1/2) hours and analysed for concentrations of glucose, insulin, C-peptide, pyruvate, lactate, alanine, and ketones. Diet, insulin dose, and exercise were kept the same on both test days.The mean blood glucose concentration at breakfast (0 minutes) was 11 mmol/l after the early injection and 10 mmol/l after the late injection. Subsequent concentrations were consistently lower with the early injection regimen than the late regimen. The greatest difference between values in the two groups was 3.7 mmol/l at 150 minutes. Mean plasma insulin concentrations were lower in the children on the early regimen than in those on the late regimen at ...Continue Reading

Citations

Jul 1, 1993·Diabetes/metabolism Reviews·M Toeller
Apr 30, 1999·Diabetes Research and Clinical Practice·H Overmann, L Heinemann
Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·J S Skyler
May 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·L Heinemann
Dec 1, 1982·Archives of Disease in Childhood·J H BaumerD C Savage
Mar 1, 1982·Archives of Disease in Childhood·A L KinmonthJ D Baum
Sep 1, 1994·Archives of Disease in Childhood·A H Sackey, I G Jefferson
Jan 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·N MüllerU A Müller
Aug 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·A L KinmonthJ P Reckless
Mar 30, 1999·Journal of Internal Medicine·A C Orre-PetterssonH J Arnqvist
Oct 1, 1995·Clinical Pharmacology and Therapeutics·D C HoweyJ R Woodworth
Mar 1, 1992·Acta Paediatrica·S M Virtanen

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