Timing of PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation: The PROTINVENT retrospective study

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
W A C Kristine KoekkoekArthur R H van Zanten

Abstract

Optimal protein intake during critical illness is unknown. Conflicting results on nutritional support during the first week of ICU stay have been published. We addressed timing of protein intake and outcomes in ICU patients requiring prolonged mechanical ventilation. We retrospectively collected nutritional and clinical data on the first 7 days of ICU admission of adult critically ill patients, who were mechanically ventilated in our ICU for at least 7 days and admitted between January 1st 2011 and December 31st 2015. Based on recent literature, patients were divided into 3 protein intake categories, <0.8 g/kg/day, 0.8-1.2 g/kg/day and >1.2 g/kg/day. Our primary aim was to identify the optimum protein dose and timing related to the lowest 6 month mortality. Secondary endpoints were ventilation duration, need for renal replacement therapy (RRT), ICU length of stay (LOS) and mortality and hospital LOS and mortality. In total 455 patients met the inclusion criteria. We found a time-dependent association of protein intake and mortality; low protein intake (<0.8 g/kg/day) before day 3 and high protein intake (>0.8 g/kg/day) after day 3 was associated with lower 6-month mortality, adjusted HR 0.609; 95% CI 0.480-0.772, p < 0.001) com...Continue Reading

Citations

Nov 13, 2019·Current Nutrition Reports·Stephen A McClaveArthur R H van Zanten
Feb 29, 2020·Pediatric Pulmonology·Glenn Y H NgJan Hau Lee
Jun 7, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Marie-Sophie Louise Yvonne de KoningArthur Raymond Hubert van Zanten
Nov 20, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Yaseen M ArabiMusharaf Sadat
Jul 1, 2020·Nutrición hospitalaria·Luis Eduardo González-SalazarAurora Elizabeth Serralde Zúñiga
Jun 20, 2019·Critical Care : the Official Journal of the Critical Care Forum·Charles Chin Han LewMichelle Miller
Feb 7, 2020·Nutrients·Elisabeth De WaeleHerbert Spapen
May 27, 2020·Critical Care : the Official Journal of the Critical Care Forum·Marie-Sophie Louise Yvonne de KoningArthur Raymond Hubert van Zanten
Jun 9, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jayshil J PatelDaren K Heyland
Mar 19, 2020·Nutrients·Moran Hellerman Itzhaki, Pierre Singer
Feb 6, 2020·Critical Care : the Official Journal of the Critical Care Forum·Kate J LambellEmma J Ridley
Nov 23, 2019·Critical Care : the Official Journal of the Critical Care Forum·Arthur Raymond Hubert van ZantenPaul Edmund Wischmeyer
Oct 25, 2020·Current Nutrition Reports·Khushboo GalaStephen A McClave
Jan 14, 2021·Journal of Intensive Care·Hanneke Pierre Franciscus Xaverius MoonenArthur Raymond Hubert van Zanten
Nov 28, 2020·Hospital Pharmacy·Roland N DickersonVanessa J Kumpf
Jan 17, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Elisabeth De WaelePaul E Wischmeyer
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ellen DresenPeter Stehle
Oct 2, 2020·Current Opinion in Critical Care·Thaddeus J Puzio, Rosemary A Kozar
Jun 9, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Qian ZhangSuming Zhou
Jul 25, 2021·Critical Care : the Official Journal of the Critical Care Forum·Zheng-Yii LeeDaren K Heyland

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