Timing of pubertal onset in girls: evidence for non-Gaussian distribution

The Journal of Clinical Endocrinology and Metabolism
A PapadimitriouA Fretzayas

Abstract

The timing of the onset of puberty is considered to approximate a normal distribution. However, because many more girls present with early than late puberty, we hypothesized that the distribution of the timing of the onset of puberty in girls might have changed. OBJECTIVE/SUBJECTS: The objective of the study was to examine the distribution of the timing of the onset of puberty in normal Greek girls. Onset of puberty, i.e. breast development (B2), was studied longitudinally in 311 prepubertal schoolgirls aged 6.4-8.2 yr until the onset of puberty. We also studied cross-sectionally 126 girls, 6-14 yr old. Clinical examinations took place in the school setting. In the longitudinal study, median of the distribution of age at B2 was 10.0 yr (with the 25th and 75th centiles being 9.2 and 10.6 yr, respectively). Skewness was -0.45 (P=0.001), suggesting a negatively skewed distribution. In the cross-sectional study, 126 subjects were found at B2. The median of the age distribution at B2 was 10.1 yr (with the 25th and 75th centiles being 9.7 and 11.2 years, respectively). Skewness was -0.44 (P=0.03), suggesting a negatively skewed distribution. A non-Gaussian distribution of the age at the onset of puberty in girls was documented. The c...Continue Reading

Citations

Sep 8, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·B García CuarteroM D Tolmo
Mar 9, 2010·Molecular and Cellular Endocrinology·Jean-Pierre BourguignonAnne-Simone Parent
Mar 9, 2011·Acta Paediatrica·Michael B AnthracopoulosKostas N Priftis
Oct 29, 2015·Journal of Endocrinological Investigation·D T PapadimitriouA Papadimitriou
Nov 9, 2016·Journal of Developmental Origins of Health and Disease·J A McDonaldM B Terry
Jan 1, 2010·The Journal of Nutrition·Anke L B GüntherAnette E Buyken
Aug 5, 2009·Pediatrics·Hua-Mei MaUNKNOWN Pubertal Study Group of the Society of Pediatric Endocrinology and Genetic Disease, Chinese Medical Association

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