Abstract
The aim of this study is to assess the complication profile and impact on patient-reported quality of life in those undergoing nipple-sparing mastectomy (NSM) with immediate breast reconstruction and subsequent prosthetic reconstruction in patients with prior breast radiation therapy (pRT) vs those receiving adjuvant post-mastectomy radiation therapy (PMRT). An IRB-approved, retrospective analysis was performed from 2002 to 2014 to identify NSM patients that underwent pRT or PMRT. A 22-item Likert scale questionnaire was administered by a third party to register patient-reported quality of life. Forty patients met criteria for outcomes analysis, and 30 patients answered the questionnaire. Mean age was 45.6 years old and mean follow-up was 3.8 years. Complication rates for the PMRT cohort were 61.9% vs 31.6% in the pRT cohort, P = .067, and those requiring operative intervention were PMRT 38.1% vs pRT 5.3%, P = .021. Nipple-areolar complex survival was 100% in the pRT vs 85.7% in the PMRT, P = .233. Breast-related quality of life scores were superior in the pRT group within multiple domains. Patients are more likely to develop complications requiring an operative intervention and have decreased breast-related quality of life whe...Continue Reading
References
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Jul 16, 2008·Plastic and Reconstructive Surgery·Scott L SpearAmir A Mafi
Nov 13, 2008·Breast Cancer Research and Treatment·F DidierJ Y Petit
Feb 28, 2009·Annals of Surgery·Bernd GerberToralf Reimer
Mar 3, 2010·Plastic and Reconstructive Surgery·Risal DjohanRandall Yetman
Dec 8, 2010·Cancer·Colleen M McCarthyAndrea L Pusic
Apr 1, 2011·Annals of Plastic Surgery·Ibrahim KhansaBernard T Lee
Nov 19, 2011·Plastic and Reconstructive Surgery·Amy S ColwellWilliam G Austen
Apr 25, 2012·Annals of Surgical Oncology·Anne Warren PeledLaura J Esserman
Jun 30, 2012·Plastic and Reconstructive Surgery·Scott L SpearMaurice Y Nahabedian
Nov 1, 2012·Plastic and Reconstructive Surgery·Mark W Clemens, Steven J Kronowitz
Aug 9, 2013·Plastic and Reconstructive Surgery·Matthew EndaraScott L Spear
Aug 27, 2013·Annals of Surgical Oncology·Suzanne B CoopeyBarbara L Smith
Feb 28, 2014·Plastic and Reconstructive Surgery·Amy S ColwellWilliam G Austen
Apr 30, 2014·Plastic and Reconstructive Surgery·Scott L SpearKetan M Patel
Jul 9, 2014·Annals of Plastic Surgery·Tara L HustonMia Talmor
Jul 30, 2014·Plastic and Reconstructive Surgery·Michael AlperovichNolan S Karp
Aug 28, 2014·Plastic and Reconstructive Surgery·Hani SbitanyRobert D Foster
Mar 27, 2015·Plastic and Reconstructive Surgery·Richard G ReishAmy S Colwell
Jul 24, 2015·Annals of Surgical Oncology·Rong TangBarbara L Smith
Jul 24, 2015·Annals of Surgical Oncology·Adam C KrajewskiTina J Hieken