Timing of surgery in ulcerative colitis in the biologic therapy era-the patient's perspective

International Journal of Colorectal Disease
J GröneMario H Mueller

Abstract

There is no general consensus regarding the ideal timing of surgery in patients with refractory ulcerative colitis (UC). Decision-making and timing of restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is influenced by treating physicians and patients themselves. The aim of this study was to determine whether or not patients would have preferred the operation to be performed earlier, at the same time, or at a later point of time and to determine the reasons for their preference. Clinical data of 193 patients with UC who have undergone IPAA were documented in a prospective database at our institution between 2004 and 2015. From this database, 190 patients were identified and a standardized custom-made questionnaire was mailed for follow-up survey. Patients who did not respond were called by telephone and encouraged to complete the questionnaire. One hundred nine questionnaires were eligible for analysis (57.4%). Average time between diagnosis and surgery was 11.2 ± 10.8 years (mean ± SD). Indications for surgery were refractory disease (70.6%), colitis-associated colorectal cancer (11.0%), high-grade dysplasia or stenosis (11.9%), and septic complications of UC (6.4%); 39 of 77 patients (50.6%) with refractory ...Continue Reading

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Citations

Nov 25, 2019·International Journal of Colorectal Disease·Olga A LavrykScott R Steele
Nov 7, 2019·Pediatric Surgery International·S Christopher DerderianDavid A Partrick
May 22, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Parambir S DulaiJames Murphy
Nov 30, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yu Meng LiKanapath Oungpasuk
Apr 2, 2020·Inflammatory Intestinal Diseases·Saki YamadaToshifumi Wakai

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