Timing of the Sense of Volition in Patients With Schizophrenia

Frontiers in Neuroscience
Sarah Pirio RichardsonMark Hallett

Abstract

Schizophrenic patients often do not have the sense that they direct their own movements or author their own thoughts (passivity phenomena). As willing must precede movement to be causal and thus generate the sense of agency, it is possible that the timing between the senses of willing and movement is shortened in schizophrenia. We tested the subjective perception of this time interval in patients with schizophrenia using a method based on Libet's paradigm, in which subjects specify a time W - the time of willing a movement - and a time M - the time that movement occurred. Patients with schizophrenia and healthy volunteers made voluntary movements at times of their own choice while looking at a fast-rotating clock on a computer screen and reported when their movements were willed and made. We recorded surface electromyography to determine the time of actual movement, and electroencephalography to record brain potentials associated with movement. Results showed a significantly reduced interval between the reported M and W in patients with respect to the healthy volunteers (p < 0.05). Specifically, patients did not report a significant difference in the timing of W at 19 ms prior to movement onset and M at 7.4 ms prior to movement...Continue Reading

References

Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·B I KarpM Hallett
May 20, 1999·Experimental Brain Research·P Haggard, M Eimer
Jun 11, 1999·British Journal of Psychology·P HaggardE Magno
Oct 3, 1999·Brain : a Journal of Neurology·A SiriguM Jeannerod
Mar 17, 2000·Brain Research. Brain Research Reviews·C D FrithD M Wolpert
Aug 23, 2002·Consciousness and Cognition·Gilberto Gomes
Feb 14, 2003·Trends in Cognitive Sciences·Daniel M. Wegner
Jun 13, 2003·Neuroreport·Patrick HaggardNicolas Franck
Feb 21, 2004·Science·David M Eagleman
Feb 21, 2004·Science·Hakwan C LauRichard E Passingham
Mar 11, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tom N Tombaugh
Mar 18, 2005·Comptes rendus biologies·Chris Frith
May 5, 2005·The Journal of Nervous and Mental Disease·Nicolas FranckPatrick Haggard
Aug 21, 2008·Brain : a Journal of Neurology·Knut SchnellEuphrosyne Gouzoulis-Mayfrank
Dec 3, 2008·The European Journal of Neuroscience·Masao Matsuhashi, Mark Hallett
Jun 10, 2014·Trends in Cognitive Sciences·Martin J Pickering, Andy Clark
Feb 18, 2015·Frontiers in Human Neuroscience·Sam Wilkinson
Apr 19, 2017·Schizophrenia Research·Kyran T Graham-SchmidtFlavie A V Waters
Jan 12, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Beier YaoKatharine N Thakkar
Jul 3, 2019·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Michele PolettiAndrea Raballo
Oct 19, 2019·Psychological Medicine·Johannes JungilligensStoyan Popkirov

❮ Previous
Next ❯

Citations

May 30, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fabio GiovannelliMassimo Cincotta

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Mark Hallett
Journal of Cognitive Neuroscience
Logan SchneiderMark Hallett
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Ou BaiMark Hallett
Annals of Neurology
Mark Hallett
© 2021 Meta ULC. All rights reserved