PMID: 2502073Jul 1, 1989Paper

Timing of UFT administration combined with surgical operation in pulmonary metastasis of rat mammary carcinoma

Gan to kagaku ryoho. Cancer & chemotherapy
X B LiH Kobayashi

Abstract

We investigated the effective timing of UFT administration combined with surgical operation for inhibiting pulmonary metastasis of spontaneously developed mammary carcinoma (SST-2) which produces 100% pulmonary metastasis in syngeneic rats after s.c. transplantation. Rats (5 rats per group) were inoculated s.c. with 1 X 10(6) SST-2 cells and administered orally with UFT (15, 30 and 60 mg/kg/day) starting 21 days after the tumor inoculation for 2 weeks. UFT at the dose of 30 mg/kg/day was found to be most effective in inhibiting pulmonary metastasis in SHR rats without any noticeable side effects. The rats inoculated s.c. with 5 X 10(4) SST-2 cells were divided into 3 groups: The 1st group was given oral administration of UFT (30 mg/kg/day) starting 7 days before surgical excision of the primary tumor for 2 weeks; 2nd group was treated with UFT starting one day after surgical operation for 2 weeks; and 3rd group was treated with UFT starting 7 days after surgical operation for 2 weeks. The number of lung colonies and survival time were compared among these 3 groups. The results clearly showed that combination of UFT and surgical operation was most effective on the 1st group when compared with the other two groups. UFT therapy, t...Continue Reading

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