Timolol maleate, a beta-adrenergic blocking agent, was studied in 30 patients with glaucoma. Significant intraocular pressure lowering was achieved with 0.5% and 1.5% solution of the drug. At seven hours following treatment, the IOP was lowered 50% from the pretreatment pressure with both strengths of timolol. There were no subjective or objective ocular or systemic side effects detected. Visual acuity and pupil response were unchanged from pretreatment levels throughout the study. beta-Adrenergic blocking agents and specifically timolol may be an important breakthrough for the medical management of glaucoma.
Atenolol 4% eye drops and glaucoma. A double-blind short-term clinical trial of a new beta1-adrenergic blocking agent
Comparative effects of SCH 19927 and timolol on intraocular pressure of conscious rabbits and relative systemic beta-blockade resulting from topical administration
Changes in intraocular pressure induced by differential forced unilateral nostril breathing, a technique that affects both brain hemisphericity and autonomic activity. A pilot study
The effect of long-term topical administration of commercial beta-blockers on the rat corneal endothelium
The effects of separate and combined topical treatment with timolol maleate and trifluormethazolamide on the intraocular pressure in normal rabbits
Pharmacokinetics, mechanisms of action, indications, and adverse effects of timolol maleate, a nonselective beta-adrenoreceptor blocking agent
Timolol versus pilocarpine separately or combined with acetazolamide-effects on intraocular pressure
Plasma and aqueous humour concentrations and systemic effects of topical betaxolol and timolol in man
Drug effects on intraocular pressure and vascular flow in the bovine perfused eye using radiolabelled microspheres
Assessing the cost-effectiveness of switching from a beta-blocker to latanoprost in the treatment of ocular hypertension
Predictive value of the efficacy of glaucoma medications in regulatory trials: Phase I-III to post-marketing studies
Comparison of intraocular pressure lowering effect of once daily morning vs evening dosing of latanoprost/timolol maleate combination
Pharmacotherapy of intraocular pressure: part I. Parasympathomimetic, sympathomimetic and sympatholytics
Effect of hydrophobic and hydrophilic additives on sol-gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel
From Eye Drops to ICU, a Case Report of Three Side Effects of Ophthalmic Timolol Maleate in the Same Patient
Comparison of the intraocular pressure-lowering effect and safety of brimonidine/timolol fixed combination and 0.5% timolol in normal-tension glaucoma patients
Natamycin and Voriconazole Exhibit Synergistic Interactions with Nonantifungal Ophthalmic Agents against Fusarium Species Ocular Isolates
Effect of a topical beta-adrenergic receptor antagonist on the dynamics of steady-state accommodation
Toxic effects of topically administered Betagan, Betoptic, and Timoptic on regenerating corneal epithelium
The effect of topical 0.5% triamterene suspension on the intraocular pressure of open angle glaucoma patients. A single dose study
A study of the efficacy of two commercial preparations of timolol maleate with special reference to side effects
Metoprolol eye drops in the treatment of glaucoma. A double-blind single-dose trial of a beta1-adrenergic blocking drug
Intraocular pressure reduction with topically administered pilocarpine, timolol and betaxolol in normal tension glaucoma
Beta 1- and beta 2-antagonist activity of topically applied betaxolol and timolol in the systemic circulation
The effect of timolol and dipivalyl-epinephrine in the treatment of the elevated intraocular pressure (author's transl)
The effect of 0.5% timolol maleate on the ocular perfusion of ocular hypertensive patients by scanning laser flowmetry
Ultrastructural effects of topical betoptic, betagan, and timoptic on the rabbit corneal endothelium
The effect of timolol and parasympathicomimetica in the treatment of the elevated intraocular pressure (author's transl)
The long-term hypotensive effect of timolol maleate compared with the effect of pilocarpine in simple and capsular glaucoma
Absorption of ocular timolol: drug concentrations and beta-receptor binding activity in the aqueous humour of the treated and contralateral eye
A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol
Effect of timolol on anterior optic nerve blood flow in patients with primary open-angle glaucoma as assessed by the Heidelberg retina flowmeter
A 6-month, randomized, double-masked comparison of latanoprost with timolol in patients with open angle glaucoma or ocular hypertension
Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol
Sustained delivery of timolol maleate from poly(lactic-co-glycolic acid)/poly(lactic acid) microspheres for over 3 months
Blind randomised non-crossover long-term trial comparing topical timolol 0.25% with timolol 0.5% in the treatment of simple chronic glaucoma
A study of the effects of four concentrations of D-timolol, 0.25% L-timolol, and placebo on intraocular pressure on patients with raised intraocular pressure
The lack of efficacy of topical beta-blockers, timolol and betaxolol on intraocular pressure in Nigerian healthy volunteers
A radioautographic study on the incorporation of 14C-bupranolol (beta-blocking agent) into the rabbit eye
Current concepts of pharmacotherapy in hypertension--ophthalmically administered beta blockers and their cardiopulmonary effects
Effect of pindolol on intraocular pressure in glaucoma: pilot study and a randomised comparison with timolol
Circadian intraocular pressure control with dorzolamide versus timolol maleate add-on treatments in primary open-angle glaucoma patients using latanoprost
Effects of systemic and topical administration of metoprolol on intraocular pressure in healthy subjects
Effects of topical 2% dorzolamide hydrochloride alone and in combination with 0.5% timolol maleate on intraocular pressure in normal feline eyes
Doppler ultrasonography of the central retinal artery in patients with diabetes and vascular disease treated with topical timolol
Fixed-dose combination of tafluprost and timolol in the treatment of open-angle glaucoma and ocular hypertension: comparison with other fixed-combination products
Initial and long-term effects of metoprolol and timolol on the intraocular pressure. A comparison in healthy subjects
An evaluation of the fixed-combination of latanoprost and timolol for use in open-angle glaucoma and ocular hypertension
Changes in intraocular pressure following a switch from latanoprost monotherapy to latanoprost/timolol fixed combination therapy in patients with primary open-angle glaucoma or ocular hypertension: results from a clinical practice database
A functional vagotomy induced by unilateral forced right nostril breathing decreases intraocular pressure in open and closed angle glaucoma
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