PMID: 2864775Aug 1, 1985

Timolol and aceclidine. A clinical study of interaction in the eye

Acta Ophthalmologica
B A van der Pol, E Wattel


In the Netherlands timolol maleate, probably the drug of first choice in antiglaucoma therapy, is often combined with other intraocular pressure lowering drugs. The efficacy of most combinations have been discussed in the literature several times, except the one with aceclidine, a parasympathetic drug, that has a reasonable popularity in Western Europe. Unlike pilocarpine, aceclidine does not seem to give a clinically significant additional pressure lowering effect in timolol pre-treated eyes. The decrease in IOP in aceclidine pre-treated eyes after single dose timolol seems to be an effect of timolol alone. Our results suggest that co-administration of timolol and aceclidine is not a rational action in antiglaucomatous therapy.


Jul 2, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M Ober, A Scharrer
Apr 1, 1977·Archives of Ophthalmology·T J Zimmerman, H E Kaufman
Oct 1, 1972·Archives of Ophthalmology·S M DranceM Schulzer
Jan 1, 1981·Klinische Monatsblätter für Augenheilkunde·W Merkle
Dec 1, 1983·Survey of Ophthalmology·M A Kass

Related Concepts

Clinical Trials
Drug Augmentation
Glaucoma, Open-Angle
Physiologic Intraocular Pressure

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