PMID: 7034454Jun 1, 1981Paper

Timolol and metoprolol in glaucoma. A comparison of the ocular hypotensive effect, local and systemic tolerance

Acta Ophthalmologica
N V Nielsen, J S Eriksen

Abstract

A double-masked cross-over comparison of the ocular hypotensive effect in 19 glaucoma patients between timolol 0.5% - a non-selective beta-blocking agent - and metoprolol 3% - a beta 1-selective blocking agent - disclosed a greater pressure lowering effect (mean 9%, median 7% more) with timolol in a treatment period of 1 month. In patients on timolol treatment 47% - 60% of the eyes could be controlled on an IOP level less than 20 mmHg compared to 34% - 47% of the eyes treated with metoprolol. Metoprolol induced a transitory burning sensation in the eyes of 58% patients compared to 26% treated with timolol. Possible signs of dry eyes manifestations as measured by break-up time, rose bengal and fluorescein 1% staining, tear osmolality and Schirmer test I developed in both the timolol (4 patients) and metoprolol (3 patients) treated group. No significant influence on blood pressure and heart rate was observed. In none had the visual field or visual acuity deteriorated at the end of the study.

References

Aug 1, 1979·The British Journal of Dermatology·T van JoostF E Ros
Jun 1, 1979·Acta Ophthalmologica·N V Nielsen, J S Eriksen
Jun 19, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·F E RosE L Greve
Jan 1, 1979·The British Journal of Ophthalmology·S E SmithV B Whitmarsh
Oct 1, 1979·American Journal of Ophthalmology·C D McMahonJ Hetherington
Oct 1, 1979·American Journal of Ophthalmology·E M Van Buskirk
Oct 1, 1979·American Journal of Ophthalmology·A Shapiro, S Merin
Jan 1, 1979·Acta Ophthalmologica·N V Nielsen, J S Eriksen
Apr 1, 1978·Archives of Ophthalmology·J P GilbardJ Santamaria
May 1, 1980·Ophthalmology·E M Van Buskirk
Jun 1, 1980·Klinische Monatsblätter für Augenheilkunde·R Marquardt, F H Wenz

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