PMID: 11912361Mar 26, 2002Paper

Timolol concentrations in rat ocular tissues and plasma after topical and intraperitoneal dosing

Journal of Glaucoma
Alexander Y TanBalwantray C Chauhan

Abstract

Topical beta-blockers, such as timolol, have been used extensively in the medical treatment of glaucoma to lower intraocular pressure (IOP). Recently, these drugs have been shown to have effects on the retinal and optic nerve circulation as well as potential neuroprotective properties. In the current study, the concentration of timolol attained in the cornea, iris-ciliary body, retina, vitreous, and plasma was measured after topical or intraperitoneal administration in rats to determine the relative contributions of each route to intraocular timolol concentrations. One group of rats received one drop of commercially available 0.5% timolol in the right eye and two drops in the left eye for 3 to 12 days. Another group of rats received one drop of 0.5% timolol in one eye only and concentrations were studied in the ocular tissues at 15, 30, 60, 120, and 240 minutes after instillation. The final group of rats received a single intraperitoneal injection of timolol ranging in concentration from 5 to 75 mg/kg after which tissue and plasma concentrations were measured 30 minutes after injection. All tissue and plasma concentrations were measured by high performance liquid chromatography. Rats that received topical timolol daily for 3 to...Continue Reading

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Citations

Nov 15, 2006·Pharmaceutical Research·Martin J KoeberleClive G Wilson
Sep 29, 2005·Acta Paediatrica·Maria KugelbergCharlotta Zetterström
Jun 23, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Neville N OsborneGlyn Chidlow
Jan 3, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Vimal SarupSansar C Sharma
Dec 4, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hae Y ParkChan K Park
Feb 11, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gustavo de Oliveira FulgêncioArmando da Silva Cunha-Júnior
May 2, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Soumyajit MajumdarRamesh Srirangam
Dec 22, 2010·Indian Journal of Ophthalmology·Sushil K VasudevanJonathan G Crowston
Nov 11, 2009·Current Eye Research·Igor KaisermanShlomo Vinker
Apr 29, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Doaa Ahmed El-SetouhyNada Sallam
Mar 27, 2013·Experimental Eye Research·Massimo Dal MontePaola Bagnoli
Nov 18, 2005·Advanced Drug Delivery Reviews·Patrick M HughesClive G Wilson
Apr 29, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Swetha Sara Philip, Gordon N Dutton
Jul 19, 2018·Purinergic Signalling·Tali Fishman JacobBilha Fischer
Feb 13, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pedro Henrique Reis da SilvaChristian Fernandes
Aug 10, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ai KidoKoji Kawakami

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