Timolol hemihydrate vs timolol maleate to treat ocular hypertension and open-angle glaucoma

American Journal of Ophthalmology
H B DubinerW C Stewart

Abstract

We compared the therapeutic efficacy and safety of timolol hemihydrate to timolol maleate in patients with ocular hypertension and chronic open-angle glaucoma. We conducted this three-month study as a multicentered, masked, parallel group comparison. Both the 0.25% and 0.5% concentrations were evaluated against similar concentrations of timolol maleate. Dosing was twice daily. An open-label, nine-month study followed the masked portion of the protocol, in which all patients received either 0.25% or 0.5% timolol hemihydrate. A total of 371 patients were included in both the 0.25% and 0.5% studies. We found statistically similar intraocular pressures with both the 0.25% (18.3 and 18.6 mm Hg for the hemihydrate and maleate groups, respectively) and 0.5% (19.9 and 19.5 mm Hg for the hemihydrate and maleate groups, respectively) concentrations of timolol hemihydrate and timolol maleate after three months of masked treatment. Likewise, peak intraocular effect at two hours after taking the medication was statistically similar between medicines at both concentrations. Likewise, both ocular and systemic safety were similar between the maleate and hemihydrate preparations at both concentrations. In the nine-month open-label protocol, the...Continue Reading

References

May 1, 1979·Survey of Ophthalmology·L L LinI Katz
Oct 2, 1976·British Medical Journal·T D Swinscow
May 1, 1992·Archives of Ophthalmology·S F Ball, E Schneider
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·W C StewartJ T Delehanty
Apr 1, 1989·Survey of Ophthalmology·M Goethals
Mar 1, 1987·Survey of Ophthalmology·G D Novack

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Citations

Aug 9, 2003·Expert Opinion on Drug Safety·Joel S Schuman
May 8, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T K MundorfW C Stewart
Jan 7, 2006·Biometrical Journal. Biometrische Zeitschrift·S Lange, G Freitag
Jan 1, 2013·Journal of Current Glaucoma Practice·William C StewartLindsay A Nelson

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