PMID: 6112728Mar 1, 1981Paper

Timolol in uncontrolled childhood glaucomas

Ophthalmology
W P Boger, D S Walton

Abstract

Thirty-four patients with childhood glaucoma who had difficult management problems in spite of conventional glaucoma medications were entered into an investigational protocol designed at a time when timolol was not available commercially. Since controlled studies in adult glaucoma had demonstrated the efficacy of timolol, a trial of the drug in these difficult childhood cases seemed justified. The study was approved by the Human Studies Committees of the Children's Hospital Medical Center and the Massachusetts Eye and Ear Infirmary, Boston, MA. These children have been followed for periods up to 2 1/2 years. In general, timolol was added to the maximum tolerated medical therapy. Definite improvement was noted in 10 patients, modest or equivocal improvement in 11, and in 13 no substantial benefit to their course occurred when timolol was added. youngsters over 5 years of age showed an average reduction in resting pulse rate of 6 beats/minute similar to that previously found in adult patients. Under 5 years of age no change in the resting pulse rate could be detected. One patient was discontinued from timolol for a possible adverse effect. The experience particularly in very young children is still quite limited, but the benefici...Continue Reading

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Citations

Jul 1, 1983·Survey of Ophthalmology·V P deLuise, D R Anderson
Jan 20, 2012·Pediatric Dermatology·Patrick McMahonIlona J Frieden
Dec 22, 2010·Indian Journal of Ophthalmology·Anil K Mandal, Debasis Chakrabarti
Jun 14, 2013·Journal of Ophthalmology·Ta C Chang, Kara M Cavuoto
Jul 1, 1985·Ophthalmology·J J Kanski, J A McAllister
Aug 18, 2009·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·David A PlagerUNKNOWN BETOPTIC S Pediatric Study Group
Feb 22, 2008·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Jess T WhitsonUNKNOWN Brinzolamide Pediatric Study Group
Apr 3, 2007·Optometry : Journal of the American Optometric Association·Nadine M Girgis, Kelly A Frantz
Jan 1, 1986·Survey of Ophthalmology·D L HooverJ Giangiacomo
May 7, 2002·American Journal of Ophthalmology·Sharon F FreedmanLaura B Enyedi
Aug 19, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Cassandra L HaysCarol B Toris
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A W Talbot, I Russell-Eggitt
Jun 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matteo SacchiPaolo Nucci
Jan 1, 1990·Survey of Ophthalmology·J J Kanski
Dec 1, 1983·Survey of Ophthalmology·T J ZimmermanK S Morgan
Jan 16, 1999·Baillière's Clinical Rheumatology·H Dollfus
Aug 18, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Amirmohsen ArbabiReza Razeghinejad
Feb 28, 2008·Optometry : Journal of the American Optometric Association·Joseph Sowka

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