PMID: 89777Jun 1, 1979

Timolol transitory manifestations of dry eyes in long term treatment

Acta Ophthalmologica
N V Nielsen, J S Eriksen


In 64 patients treated with timolol eye drops (0.25% and 0.50%) seven patients developed transitory sensation of dry eyes. Two of these subjects also had xerostomia. Conjunctival and corneal defects were disclosed simultaneously with rose bengal staining. Morphologically, some of these lesions might have the same appearance as of the early stages of kerato-conjunctivitis sicca. A reduction of Schirmer test and break-up time was noted. The duration of symptoms ranged from 3 to 13 days. The mean time of treatment at the début of symptoms was 30 weeks (range 23--43 weeks). A pathogenesis of these seemingly harmless findings is at the present obscure. In none of our patients was the treatment discontinued and the symptoms did not reappear.


May 1, 1977·The British Journal of Ophthalmology·I A MackieJ M Pescod
Oct 1, 1978·Acta Ophthalmologica·E Kerty, I Hørven
Jun 7, 1975·British Medical Journal·P J Holt, E Waddington
Jan 1, 1976·Acta Medica Scandinavica·H A JensenJ Sondergaard
Apr 1, 1977·Archives of Ophthalmology·T J Zimmerman, H E Kaufman
Feb 1, 1978·Acta Ophthalmologica·R RitchS M Podos
Jun 1, 1978·Archives of Ophthalmology·R L RadiusM E Langham
Oct 1, 1976·The British Journal of Ophthalmology·A Garner, A H Rahi
Mar 1, 1973·The British Journal of Ophthalmology·J Vale, C I Phillips
Nov 9, 1974·British Medical Journal·R H FelixM G Dahl


Jan 1, 1989·International Ophthalmology·A D Petounis, P Akritopoulos
Feb 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·K Y WuH Z Wang
Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·L BonomiS Michieletto
Nov 15, 1984·Documenta Ophthalmologica. Advances in Ophthalmology·L ThörigN J van Haeringen
Dec 1, 1980·Acta Ophthalmologica·B M Calissendorff, N Marén
Dec 1, 1980·International Ophthalmology·Y Kitazawa, H Tsuchisaka
Mar 8, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kaevalin LekhanontRoy S Chuck
Sep 4, 2015·The Journal of Small Animal Practice·R StavinohovaC Busse
Aug 1, 1980·Acta Ophthalmologica·G K KrieglsteinW Leydhecker

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