Timolol/pilocarpine combination eye drops in open angle glaucoma and in ocular hypertension. A controlled randomized study

Acta Ophthalmologica
G Høvding, H Aasved


The effect of a newly developed ophthalmic solution containing both 0.5% timolol and 2% resp. 4% pilocarpine was compared with that of timolol 0.5% eye drops alone in 93 patients with manifest simple or capsular glaucoma or ocular hypertension. The medications were administered twice daily. The absolute additive effect of pilocarpine was small, although the combined solutions caused a statistically significantly greater reduction of the intraocular pressure than that achieved by timolol alone. This additional effect appeared to last at least 12 h. The effect of the test solutions containing 2% resp. 4% pilocarpine was very similar. Apart from the well-known effects of the pilocarpine-induced miosis, the combined test medications were generally well tolerated.


Oct 1, 1978·Acta Ophthalmologica·E Kerty, I Hørven
Jul 2, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M Ober, A Scharrer
Apr 1, 1977·Archives of Ophthalmology·T J Zimmerman, H E Kaufman
Nov 1, 1978·Archives of Ophthalmology·R L Coakes, R F Brubaker
Sep 1, 1979·American Journal of Ophthalmology·E U Keates
Aug 1, 1979·Acta Ophthalmologica·H AasvedJ E Slagsvold
Jan 1, 1979·Acta Ophthalmologica·N V Nielsen, J S Eriksen
Nov 1, 1977·The British Journal of Ophthalmology·R DavidM H Luntz
Sep 1, 1970·Journal of Pharmaceutical Sciences·P H ChungJ L Lach
Nov 1, 1970·Archives of Ophthalmology·L S Harris, M A Galin
Mar 1, 1982·Ophthalmology·W M Hart, B Becker
Sep 1, 1982·Ophthalmology·W M Grant, J F Burke
Mar 1, 1980·Archives of Ophthalmology·I Hass, S M Drance
Nov 1, 1981·American Journal of Ophthalmology·S E Norell
Jan 1, 1964·American Journal of Ophthalmology·A E KRILL, F W NEWELL

Related Concepts

Clinical Trials
Glaucoma, Open-Angle
Ocular Hypertension
Ophthalmic Solution

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