TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma

British Journal of Cancer
D G PoweR E Hewitt

Abstract

In this study, we report on the distribution of tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) mRNA expression in human normal colorectal mucosa, adenomas and adenocarcinomas. Northern blot analysis showed five TIMP-3 mRNA transcripts to be present in normal mucosal epithelium and in moderately and poorly differentiated carcinoma. Adenomas and well-differentiated carcinomas were not examined in this part of the investigation. In situ hybridization studies showed no detectable TIMP-3 mRNA in normal and adenomatous tissue. In contrast, TIMP-3 mRNA is localized to stromal fibroblast-like cells in colorectal carcinomas, with an increased incidence in moderately and poorly differentiated groups compared with well-differentiated carcinomas. Expression in both the moderately and the poorly differentiated tumour groups was strongest at the tumour invasive edge; none of the poorly differentiated carcinomas showed mRNA expression in regions ahead of the invasive edge, compared with 3 of 12 of the moderate group. To our knowledge, this is the first detailed report on the regional localization of TIMP-3 mRNA in colorectal tumours. We suggest that the lack of TIMP-3 mRNA expression in host stromal tissues ahead of poorly differenti...Continue Reading

Citations

Feb 7, 2001·Journal of the National Cancer Institute·M Hidalgo, S G Eckhardt
Jul 5, 2001·British Journal of Cancer·L L GroftD R Edwards
Mar 12, 2005·World Journal of Gastroenterology : WJG·Elzbieta SkrzydlewskaStanislaw Sulkowski
Apr 25, 2007·International Journal of Cancer. Journal International Du Cancer·Marja HilskaMatti Laato
Nov 5, 1999·The Journal of Pathology·S Curran, G I Murray
Jan 12, 2008·World Journal of Gastroenterology : WJG·Eric SmithPaul A Drew
Feb 13, 2014·Cancers·Anan H SaidGuofeng Xie
Apr 29, 1999·Annals of Medicine·V M Kähäri, U Saarialho-Kere
Apr 12, 2002·Oncogene·Yangfu JiangY Eric Shi
Mar 2, 2011·Journal of Molecular Recognition : JMR·Helena C CastroCarlos R Rodrigues

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