TINCR: An lncRNA with dual functions in the carcinogenesis process

Non-coding RNA Research
Soudeh Ghafouri-FardMir Davood Omrani

Abstract

Long non-coding RNAs (lncRNAs) have prominent roles in the pathogenesis of human cancers. Several studies have shown oncogenic or tumor suppressor roles of lncRNAs in different human tissues. Thus, these transcripts have been regarded as putative targets in treatment of cancer. The lncRNA terminal differentiation-induced non-coding RNA (TINCR) has an especial position in this regard, as it exerts different opposite roles in the pathogenesis of different human cancers. While it is up-regulated in gastric, esophageal, bladder and breast cancer; it is down-regulated in glioma, retinoblastoma and prostate cancer. Notably, data regarding expression profile of this lncRNA in a number of human cancers such as colon cancer, squamous cell carcinoma, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC) are controversial. Expression level of this lncRNA has been associated with clinical outcome in patients with gastric cancer, colorectal cancer, NSCLC and head and neck squamous cell carcinoma. Moreover, Kaplan-Meier analyses have shown correlation between expression levels of TINCR and patients survival in patients with lung cancer and HCC. A number of cellular pathways such as Wnt/β-catenin, ERK1/2-SP3 and MAPK signaling...Continue Reading

Citations

Nov 6, 2020·Seminars in Cancer Biology·Mohammad Fahad UllahFaisel M Abuduhier
Apr 17, 2021·The FEBS Journal·Subhayan Sur, Ratna B Ray
Jul 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shahin Alizadeh-FanalouForogh Mohammadi

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Methods Mentioned

BETA
RNA-seq
acetylation
xenograft
surgical resection

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